Detailed information of TA system TA164781

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 4329171..4329390
• Replicon: chromosome
• Accession: NZ_CP057101
• Organism: Escherichia fergusonii strain RHB38-C04

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: HVZ67_RS20780
• Protein ID: WP_001295224.1
• Coordinates: 4329171..4329278 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4329327..4329390 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ67_RS20750	4324219..4324407	-	189	WP_001063310.1	YhjR family protein	-
HVZ67_RS20755	4324694..4326253	+	1560	WP_001070267.1	cellulose biosynthesis protein BcsE	-
HVZ67_RS20760	4326250..4326441	+	192	WP_046077700.1	cellulose biosynthesis protein BcsF	-
HVZ67_RS20765	4326438..4328117	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HVZ67_RS20770	4328204..4328311	-	108	WP_114091462.1	type I toxin-antitoxin system toxin Ldr family protein	-
HVZ67_RS20775	4328687..4328794	-	108	WP_002431793.1	type I toxin-antitoxin system toxin Ldr family protein	-
HVZ67_RS20780	4329171..4329278	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4329327..4329390	+	64	NuclAT_15	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_15	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_15	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_15	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_16	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_16	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_16	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_16	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_17	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_17	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_17	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_17	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_18	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_18	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_18	-	Antitoxin
-	4329327..4329390	+	64	NuclAT_18	-	Antitoxin
-	4329327..4329392	+	66	NuclAT_13	-	-
-	4329327..4329392	+	66	NuclAT_13	-	-
-	4329327..4329392	+	66	NuclAT_13	-	-
-	4329327..4329392	+	66	NuclAT_13	-	-
-	4329327..4329392	+	66	NuclAT_14	-	-
-	4329327..4329392	+	66	NuclAT_14	-	-
-	4329327..4329392	+	66	NuclAT_14	-	-
-	4329327..4329392	+	66	NuclAT_14	-	-
HVZ67_RS20785	4329715..4330911	+	1197	WP_181465070.1	methionine gamma-lyase	-
HVZ67_RS20790	4331161..4332459	+	1299	WP_001152711.1	amino acid permease	-
HVZ67_RS20795	4332475..4333686	-	1212	WP_125282763.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T164781 WP_001295224.1 NZ_CP057101:c4329278-4329171 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T164781 NZ_CP073285:327908-328276 [Klebsiella pneumoniae subsp. ozaenae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACTGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Nucleotide

• Length: 64 bp

>AT164781 NZ_CP057101:4329327-4329390 [Escherichia fergusonii]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin