Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2706183..2706843 Replicon chromosome
Accession NZ_CP057101
Organism Escherichia fergusonii strain RHB38-C04

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVZ67_RS12955 Protein ID WP_046077353.1
Coordinates 2706490..2706843 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HVZ67_RS12950 Protein ID WP_001553123.1
Coordinates 2706183..2706485 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ67_RS12930 2701542..2702339 + 798 WP_046077351.1 DgsA anti-repressor MtfA -
HVZ67_RS12940 2702677..2703938 + 1262 Protein_2523 integrase arm-type DNA-binding domain-containing protein -
HVZ67_RS12945 2704795..2705679 - 885 WP_046077352.1 integrase domain-containing protein -
HVZ67_RS12950 2706183..2706485 - 303 WP_001553123.1 XRE family transcriptional regulator Antitoxin
HVZ67_RS12955 2706490..2706843 - 354 WP_046077353.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVZ67_RS12960 2707340..2707561 - 222 WP_046077354.1 helix-turn-helix domain-containing protein -
HVZ67_RS12965 2707558..2708025 - 468 WP_181576172.1 hypothetical protein -
HVZ67_RS12970 2708912..2709691 + 780 WP_046077393.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13486.42 Da        Isoelectric Point: 8.9507

>T164777 WP_046077353.1 NZ_CP057101:c2706843-2706490 [Escherichia fergusonii]
VWTIKTTDMFDHWFISLNDTDRASVLAALLVLREKGPGLSRPYADTIRGSRYSNMKELRIQSRGDPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPIADREFTNWLNTLKEKE

Download         Length: 354 bp

>T164777 NZ_CP073283:1279670-1280026 [Bifidobacterium longum subsp. infantis]
ATGATGAAGACTGATCCGCGCCAGTTCGAGATATGGTGGGTGCCGTTCGCTTTTCCCGACAAGCCAGGCAAAGCGAAGAA
CCATCCCAGCGTGATCCTCCAATGGGACGACGGCACCCGCATCGCCTTGATGACCAAGGTCACCGGCAACACCTGGCGCG
ACGAACCGGGCTATGTGGTGCTGCGTGACTGGCAGGACGCGGGACTGAGCAAGCCCAGCGCCGTGCGATGCTCGCAACTG
CTGCGGCTGCCAAGCAATCTTTTCCTCGACGACGGCCCGACAGGAAGACTTTCGGCATATGATGCCGGCCGCGTCGCCTG
GGCGATCAACGAACTCTATCCGGGCCTACTAGCCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11084.82 Da        Isoelectric Point: 5.1786

>AT164777 WP_001553123.1 NZ_CP057101:c2706485-2706183 [Escherichia fergusonii]
MGRTLEQLIADEKPEVVDEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp

>AT164777 NZ_CP073283:1279387-1279683 [Bifidobacterium longum subsp. infantis]
ATGATGGCTATCAAGGAGAAGACCACAATCAGTCTGGATGCGCAGACCAAGCGTGACGGCATCGCCATACTTGACGCCAT
GGGGTTGAACCTGAGCACGTTTGCCGAAATGTCTCTCAGACAATTGGTACGCGACGGGCGTCTGCCATTCACGCCAAGCG
TCCGCCCTTCATTCGAAAAAGACAACGAGGGATATCCCCTGTTCAAAGCGAACATGGATGATCCCCGCATCGTGACGCCC
CAGATACGTGATGGTGCCGTGATCCTGCCGGAGGGTTGGGACGATGATGAAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References