Detailed information of TA system TA164766

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 694593..694851
• Replicon: chromosome
• Accession: NZ_CP057101
• Organism: Escherichia fergusonii strain RHB38-C04

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVZ67_RS03385
• Protein ID: WP_000935262.1
• Coordinates: 694593..694802 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	694794..694851 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ67_RS03365	689659..690246	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HVZ67_RS03370	690280..690846	-	567	WP_000528529.1	acetate uptake transporter	-
HVZ67_RS03375	691354..693270	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVZ67_RS03380	693359..694489	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVZ67_RS03385	694593..694802	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	694794..694851	+	58	-	-	Antitoxin
HVZ67_RS03390	695286..696452	+	1167	WP_046076806.1	Na+/H+ antiporter NhaA	-
HVZ67_RS03395	696520..697419	+	900	WP_000019050.1	transcriptional activator NhaR	-
HVZ67_RS03400	697515..697778	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVZ67_RS03405	697881..698099	+	219	WP_046076805.1	DUF2575 family protein	-
HVZ67_RS03410	698107..699048	+	942	WP_046076804.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T164766 WP_000935262.1 NZ_CP057101:c694802-694593 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T164766 NZ_CP073263:c408416-408036 [Duffyella gerundensis]
ATGAGTTTGCAGGGAGAGAAGCCACTAATCTGGCTCGGTAGCAGTAAAAAGGATCTATTGTCACTACCTAAAGAAGTGCA
ACGTTTCTTTGGCTTTGCGTTGGACTTCGCCCAACATGGTGAGAAGCATGACAGTGCGAAGGTTCTTAAAGGTTTTGGTG
ATGCCGGTGTTCTTGAAGTGGTTGAGGACGATATGGGTGGTACTTACCGCGCTGTATATACCGTCAAGTTTGATGAGGCC
GTGTTTGTACTTCACGCTTTCCAGAAAAAGAGCAAGCAGGGAATAGCGACGCCCAGGGAAGACATGGAGATTATCAGAAA
CCGGCTTAAAGTAGCTGCTGTAGTAGCCCAGGAGATAAAAAATGGAAAACAAAATCATTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT164766 NZ_CP057101:694794-694851 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin