Detailed information of TA system TA164745

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4479607..4479864
• Replicon: chromosome
• Accession: NZ_CP057093
• Organism: Escherichia fergusonii strain RHB38-C07

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: F4T5C6
• Locus tag: HVZ69_RS21790
• Protein ID: WP_001135731.1
• Coordinates: 4479607..4479759 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4479816..4479864 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ69_RS21765	4474801..4475775	+	975	WP_181588062.1	glyoxylate/hydroxypyruvate reductase GhrB	-
HVZ69_RS21770	4475868..4476578	-	711	WP_181588063.1	DUF3053 domain-containing protein	-
HVZ69_RS21775	4477016..4478386	+	1371	WP_181588064.1	MFS transporter	-
HVZ69_RS21780	4478636..4478926	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVZ69_RS21785	4479207..4479419	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVZ69_RS21790	4479607..4479759	-	153	WP_001135731.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4479816..4479864	+	49	-	-	Antitoxin
HVZ69_RS21795	4480081..4482150	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
HVZ69_RS21800	4482160..4483071	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HVZ69_RS21805	4483167..4483466	-	300	WP_024256552.1	YsaB family lipoprotein	-
HVZ69_RS21810	4483638..4484633	+	996	WP_181588065.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 6025.30 Da
• Isoelectric Point: 7.7169

>T164745 WP_001135731.1 NZ_CP057093:c4479759-4479607 [Escherichia fergusonii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T164745 NZ_CP073244:c1490954-1490703 [Proteus terrae subsp. cibarius]
ATGAAAACGATAAATTATACAGAAGCAAGACAAAACTTAACTTCAATTATGAATGAAACAATTGATGATAGAGTACCCAT
CATGATCACAAGGCAAAAGGGTATTCCATGTGTTCTTTTATCTCTTGATGAATACCAAGCACTAGAAGAAACTGCCTATC
TGTTACGATCTCCAGCGAATGCGCGCCATTTGCTCGATTCTATTGATGAACTGAACCAAGGTAAAGGTATAGAAAAGGAT
ATAACGGAATGA

Antitoxin

Nucleotide

• Length: 49 bp

>AT164745 NZ_CP057093:4479816-4479864 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A061YDD9

Antitoxin