Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-sokC/Ldr(toxin)
Location 4450823..4451042 Replicon chromosome
Accession NZ_CP057093
Organism Escherichia fergusonii strain RHB38-C07

Toxin (Protein)


Gene name ldrD Uniprot ID S1NWX0
Locus tag HVZ69_RS21660 Protein ID WP_001295224.1
Coordinates 4450823..4450930 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4450979..4451042 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ69_RS21630 4445883..4446071 - 189 WP_001063310.1 YhjR family protein -
HVZ69_RS21635 4446358..4447917 + 1560 WP_001070267.1 cellulose biosynthesis protein BcsE -
HVZ69_RS21640 4447914..4448105 + 192 WP_000981122.1 cellulose biosynthesis protein BcsF -
HVZ69_RS21645 4448102..4449781 + 1680 WP_000192007.1 cellulose biosynthesis protein BcsG -
HVZ69_RS21650 4449868..4449975 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- 4450033..4450087 + 55 NuclAT_16 - -
- 4450033..4450087 + 55 NuclAT_16 - -
- 4450033..4450087 + 55 NuclAT_16 - -
- 4450033..4450087 + 55 NuclAT_16 - -
- 4450033..4450087 + 55 NuclAT_19 - -
- 4450033..4450087 + 55 NuclAT_19 - -
- 4450033..4450087 + 55 NuclAT_19 - -
- 4450033..4450087 + 55 NuclAT_19 - -
- 4450033..4450087 + 55 NuclAT_22 - -
- 4450033..4450087 + 55 NuclAT_22 - -
- 4450033..4450087 + 55 NuclAT_22 - -
- 4450033..4450087 + 55 NuclAT_22 - -
- 4450033..4450087 + 55 NuclAT_25 - -
- 4450033..4450087 + 55 NuclAT_25 - -
- 4450033..4450087 + 55 NuclAT_25 - -
- 4450033..4450087 + 55 NuclAT_25 - -
- 4450033..4450089 + 57 NuclAT_10 - -
- 4450033..4450089 + 57 NuclAT_10 - -
- 4450033..4450089 + 57 NuclAT_10 - -
- 4450033..4450089 + 57 NuclAT_10 - -
- 4450033..4450089 + 57 NuclAT_13 - -
- 4450033..4450089 + 57 NuclAT_13 - -
- 4450033..4450089 + 57 NuclAT_13 - -
- 4450033..4450089 + 57 NuclAT_13 - -
HVZ69_RS21655 4450351..4450458 - 108 WP_181588055.1 type I toxin-antitoxin system toxin Ldr family protein -
- 4450507..4450570 + 64 NuclAT_15 - -
- 4450507..4450570 + 64 NuclAT_15 - -
- 4450507..4450570 + 64 NuclAT_15 - -
- 4450507..4450570 + 64 NuclAT_15 - -
- 4450507..4450570 + 64 NuclAT_18 - -
- 4450507..4450570 + 64 NuclAT_18 - -
- 4450507..4450570 + 64 NuclAT_18 - -
- 4450507..4450570 + 64 NuclAT_18 - -
- 4450507..4450570 + 64 NuclAT_21 - -
- 4450507..4450570 + 64 NuclAT_21 - -
- 4450507..4450570 + 64 NuclAT_21 - -
- 4450507..4450570 + 64 NuclAT_21 - -
- 4450507..4450570 + 64 NuclAT_24 - -
- 4450507..4450570 + 64 NuclAT_24 - -
- 4450507..4450570 + 64 NuclAT_24 - -
- 4450507..4450570 + 64 NuclAT_24 - -
- 4450507..4450572 + 66 NuclAT_12 - -
- 4450507..4450572 + 66 NuclAT_12 - -
- 4450507..4450572 + 66 NuclAT_12 - -
- 4450507..4450572 + 66 NuclAT_12 - -
- 4450507..4450572 + 66 NuclAT_9 - -
- 4450507..4450572 + 66 NuclAT_9 - -
- 4450507..4450572 + 66 NuclAT_9 - -
- 4450507..4450572 + 66 NuclAT_9 - -
HVZ69_RS21660 4450823..4450930 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 4450979..4451042 + 64 NuclAT_14 - Antitoxin
- 4450979..4451042 + 64 NuclAT_14 - Antitoxin
- 4450979..4451042 + 64 NuclAT_14 - Antitoxin
- 4450979..4451042 + 64 NuclAT_14 - Antitoxin
- 4450979..4451042 + 64 NuclAT_17 - Antitoxin
- 4450979..4451042 + 64 NuclAT_17 - Antitoxin
- 4450979..4451042 + 64 NuclAT_17 - Antitoxin
- 4450979..4451042 + 64 NuclAT_17 - Antitoxin
- 4450979..4451042 + 64 NuclAT_20 - Antitoxin
- 4450979..4451042 + 64 NuclAT_20 - Antitoxin
- 4450979..4451042 + 64 NuclAT_20 - Antitoxin
- 4450979..4451042 + 64 NuclAT_20 - Antitoxin
- 4450979..4451042 + 64 NuclAT_23 - Antitoxin
- 4450979..4451042 + 64 NuclAT_23 - Antitoxin
- 4450979..4451042 + 64 NuclAT_23 - Antitoxin
- 4450979..4451042 + 64 NuclAT_23 - Antitoxin
- 4450979..4451044 + 66 NuclAT_11 - -
- 4450979..4451044 + 66 NuclAT_11 - -
- 4450979..4451044 + 66 NuclAT_11 - -
- 4450979..4451044 + 66 NuclAT_11 - -
- 4450979..4451044 + 66 NuclAT_8 - -
- 4450979..4451044 + 66 NuclAT_8 - -
- 4450979..4451044 + 66 NuclAT_8 - -
- 4450979..4451044 + 66 NuclAT_8 - -
HVZ69_RS21665 4451367..4452563 + 1197 WP_181588056.1 methionine gamma-lyase -
HVZ69_RS21670 4452812..4454110 + 1299 WP_181588057.1 amino acid permease -
HVZ69_RS21675 4454126..4455337 - 1212 WP_181588058.1 sigma 54-interacting transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3882.70 Da        Isoelectric Point: 9.0157

>T164743 WP_001295224.1 NZ_CP057093:c4450930-4450823 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T164743 NZ_CP073244:1249233-1250546 [Proteus terrae subsp. cibarius]
ATGGCGAGCCTTGATGTGTATATGAATGAATATTATGTGGGTATTTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATGCTGAAGATTGGGTTAATCAACCAGGAAGTCGCCCTATATCTCTTTCTATGCCACTACAACTTCAAGAATATCAAG
GAGATTGTGTCTATAATTTCTTTGATAATCTTTTACCTGATAATCCTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCAAACTCAAATCAACCATTTGATCTATTAACTGCCGTGGGTGCAGATACGGTTGGTGCATTACGGTTACTTCCTAGTAG
TAGTACGCCAGCTAATATAAAAAAAATAGAATATAACAAACTTGATAACGCTGAACTTGAAAAAATACTATTAGGATATC
AATCCAATACACCACTCGGTATGCTTGAAGAATATACTGATTTCAGAATTTCTATCGCTGGAGCGCAAGAAAAAACAGCA
TTACTTTTAAAAGATGATCATTGGTGTGTGCCACACAATAATACGCCGACTACACATATTATTAAGCTACCCATTGGTGT
TATTGAAGGGCATTCCTATACAATGGATTTATCCGATAGTGTAGAAAATGAATATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCTGTTCCTCACTGTTTTATTGTTAAAACAGAAAATATTAAAGCGCTTGCTGTAGAACGCTTTGATAGAAAA
TACTCATCAGATAAATCGTGGATAATCCGCTTACCCCAAGAAGATTTTTGCCAAATTCTAAATATACCTTCAGCTCTAAA
ATATGAAAATGAAGGGGGGCCTGGCATTATTGATATCATGAATTATTTGCTTGGTTCATCAAATGCTGATCAAGACCGTT
TTCATTTTATGAAGGCACAAGTACTATTTTGGCTTTTAGCTGCAACAGATGGGCATGCAAAGAATTTCTCTGTTTTTATC
AATCAAGAAGGACGTTTTCACCTCACGCCTCTTTATGACATCATGTCTATCTATCCCAATTTTGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTCGCTATGGGATTACAGGCAAGCCGAGGCAAAAAATATGCCATAGAGCAAATTTTTCCTCGCC
ATTTTTACCAAACAGCTGAAGCAGCCAGTTTCGATCCTTCATTGATGACTGATATTCTTCGTTATTTTTATAAAGAAATG
GACGATGCCATCAAGCGCGTAAAACAACAACTACCTGATGATTTTCCTTCTGAAATTAGCAGTAAAATATTGAATGGAAT
GAAAACACGCTCCGCAAGATTAGCCAATATTTAG

Antitoxin


Download         Length: 64 bp

>AT164743 NZ_CP057093:4450979-4451042 [Escherichia fergusonii]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGAATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TSJ7

Antitoxin

Download structure file

References