Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 1932076..1932301 Replicon chromosome
Accession NZ_CP057093
Organism Escherichia fergusonii strain RHB38-C07

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag HVZ69_RS09475 Protein ID WP_000813254.1
Coordinates 1932146..1932301 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 1932076..1932134 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ69_RS09435 1927139..1927357 - 219 WP_001171942.1 hypothetical protein -
HVZ69_RS09440 1927429..1927728 - 300 WP_050582285.1 hypothetical protein -
HVZ69_RS09445 1928067..1928711 - 645 WP_000444613.1 LexA family transcriptional regulator -
HVZ69_RS09450 1928811..1929038 + 228 WP_001261754.1 cell division control protein -
HVZ69_RS09455 1929035..1929460 + 426 WP_000693850.1 Rha family transcriptional regulator -
HVZ69_RS09460 1929532..1930602 + 1071 WP_023154928.1 phage replisome organizer protein -
HVZ69_RS09465 1930643..1931068 + 426 WP_021546098.1 DUF977 family protein -
HVZ69_RS09470 1931243..1931908 + 666 WP_000150294.1 epoxyqueuosine reductase QueH -
- 1932076..1932134 - 59 - - Antitoxin
HVZ69_RS09475 1932146..1932301 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
HVZ69_RS09480 1932445..1932837 + 393 WP_000737636.1 hypothetical protein -
HVZ69_RS09485 1933134..1933412 + 279 WP_113488262.1 hypothetical protein -
HVZ69_RS09490 1933414..1934469 + 1056 WP_181598227.1 DUF968 domain-containing protein -
HVZ69_RS09495 1934470..1934835 + 366 WP_000139992.1 RusA family crossover junction endodeoxyribonuclease -
HVZ69_RS09500 1934832..1935521 + 690 WP_001064896.1 antiterminator -
HVZ69_RS09525 1936318..1936533 + 216 WP_000839572.1 class II holin family protein -
HVZ69_RS09530 1936538..1936888 + 351 WP_001545374.1 YdfR family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1912476..1960469 47993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-47)


Sequences


Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T164723 WP_000813254.1 NZ_CP057093:1932146-1932301 [Escherichia fergusonii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T164723 NZ_CP073115:2199724-2199987 [Neisseria subflava]
GTGAGGAAGCACCGTTTTACCGCTGATGCCGCCGAAGATTTGGCATATTGGAAAAAACATGATGCTAGGAAGGTTGAACG
GATTAAGTTGCTTTTGGAAGATATTAAAGCCAACCATCCGAAGGGAATCGGTAAACCTGAACCACTTCGTCACCATAAAT
CGGGCTTATGGTCGCGAAGGATTGATCGGGAACACCGTTTGGTTTATTCGGTAGATGAAGATACGGTAACTGTATATGCT
TGCCGATACCATTACGAACGCTAA

Antitoxin


Download         Length: 59 bp

>AT164723 NZ_CP057093:c1932134-1932076 [Escherichia fergusonii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0


Antitoxin

Download structure file

References