Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 1932076..1932301 | Replicon | chromosome |
Accession | NZ_CP057093 | ||
Organism | Escherichia fergusonii strain RHB38-C07 |
Toxin (Protein)
Gene name | hokW | Uniprot ID | S1ELB5 |
Locus tag | HVZ69_RS09475 | Protein ID | WP_000813254.1 |
Coordinates | 1932146..1932301 (+) | Length | 52 a.a. |
Antitoxin (RNA)
Gene name | sokW | ||
Locus tag | - | ||
Coordinates | 1932076..1932134 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HVZ69_RS09435 | 1927139..1927357 | - | 219 | WP_001171942.1 | hypothetical protein | - |
HVZ69_RS09440 | 1927429..1927728 | - | 300 | WP_050582285.1 | hypothetical protein | - |
HVZ69_RS09445 | 1928067..1928711 | - | 645 | WP_000444613.1 | LexA family transcriptional regulator | - |
HVZ69_RS09450 | 1928811..1929038 | + | 228 | WP_001261754.1 | cell division control protein | - |
HVZ69_RS09455 | 1929035..1929460 | + | 426 | WP_000693850.1 | Rha family transcriptional regulator | - |
HVZ69_RS09460 | 1929532..1930602 | + | 1071 | WP_023154928.1 | phage replisome organizer protein | - |
HVZ69_RS09465 | 1930643..1931068 | + | 426 | WP_021546098.1 | DUF977 family protein | - |
HVZ69_RS09470 | 1931243..1931908 | + | 666 | WP_000150294.1 | epoxyqueuosine reductase QueH | - |
- | 1932076..1932134 | - | 59 | - | - | Antitoxin |
HVZ69_RS09475 | 1932146..1932301 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | Toxin |
HVZ69_RS09480 | 1932445..1932837 | + | 393 | WP_000737636.1 | hypothetical protein | - |
HVZ69_RS09485 | 1933134..1933412 | + | 279 | WP_113488262.1 | hypothetical protein | - |
HVZ69_RS09490 | 1933414..1934469 | + | 1056 | WP_181598227.1 | DUF968 domain-containing protein | - |
HVZ69_RS09495 | 1934470..1934835 | + | 366 | WP_000139992.1 | RusA family crossover junction endodeoxyribonuclease | - |
HVZ69_RS09500 | 1934832..1935521 | + | 690 | WP_001064896.1 | antiterminator | - |
HVZ69_RS09525 | 1936318..1936533 | + | 216 | WP_000839572.1 | class II holin family protein | - |
HVZ69_RS09530 | 1936538..1936888 | + | 351 | WP_001545374.1 | YdfR family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1912476..1960469 | 47993 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 52 a.a. Molecular weight: 5736.89 Da Isoelectric Point: 6.1531
>T164723 WP_000813254.1 NZ_CP057093:1932146-1932301 [Escherichia fergusonii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE
Download Length: 156 bp
>T164723 NZ_CP073115:2199724-2199987 [Neisseria subflava]
GTGAGGAAGCACCGTTTTACCGCTGATGCCGCCGAAGATTTGGCATATTGGAAAAAACATGATGCTAGGAAGGTTGAACG
GATTAAGTTGCTTTTGGAAGATATTAAAGCCAACCATCCGAAGGGAATCGGTAAACCTGAACCACTTCGTCACCATAAAT
CGGGCTTATGGTCGCGAAGGATTGATCGGGAACACCGTTTGGTTTATTCGGTAGATGAAGATACGGTAACTGTATATGCT
TGCCGATACCATTACGAACGCTAA
GTGAGGAAGCACCGTTTTACCGCTGATGCCGCCGAAGATTTGGCATATTGGAAAAAACATGATGCTAGGAAGGTTGAACG
GATTAAGTTGCTTTTGGAAGATATTAAAGCCAACCATCCGAAGGGAATCGGTAAACCTGAACCACTTCGTCACCATAAAT
CGGGCTTATGGTCGCGAAGGATTGATCGGGAACACCGTTTGGTTTATTCGGTAGATGAAGATACGGTAACTGTATATGCT
TGCCGATACCATTACGAACGCTAA
Antitoxin
Download Length: 59 bp
>AT164723 NZ_CP057093:c1932134-1932076 [Escherichia fergusonii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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