Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1827273..1827775 Replicon chromosome
Accession NZ_CP057093
Organism Escherichia fergusonii strain RHB38-C07

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HVZ69_RS08765 Protein ID WP_000767829.1
Coordinates 1827521..1827775 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HVZ69_RS08760 Protein ID WP_128880351.1
Coordinates 1827273..1827524 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ69_RS08735 1822450..1823517 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HVZ69_RS08740 1823517..1824587 - 1071 WP_138957225.1 histidinol-phosphate transaminase -
HVZ69_RS08745 1824584..1825888 - 1305 WP_181588649.1 histidinol dehydrogenase -
HVZ69_RS08750 1825894..1826793 - 900 WP_000131779.1 ATP phosphoribosyltransferase -
HVZ69_RS08755 1826939..1826989 - 51 WP_001364200.1 his operon leader peptide -
HVZ69_RS08760 1827273..1827524 + 252 WP_128880351.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HVZ69_RS08765 1827521..1827775 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HVZ69_RS08770 1827858..1828682 + 825 WP_000754745.1 SDR family oxidoreductase -
HVZ69_RS08775 1828728..1829657 + 930 WP_181588650.1 LysR family transcriptional regulator -
HVZ69_RS08780 1829872..1829934 + 63 WP_010723108.1 membrane protein YoeI -
HVZ69_RS08785 1829924..1831282 + 1359 WP_000019201.1 putrescine/proton symporter PlaP -
HVZ69_RS08790 1831461..1832519 + 1059 WP_046080827.1 transport protein YeeE -
HVZ69_RS08795 1832533..1832760 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T164722 WP_000767829.1 NZ_CP057093:1827521-1827775 [Escherichia fergusonii]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T164722 NZ_CP073115:2199479-2199727 [Neisseria subflava]
ATGGACTATGTAATCAGCTACACCGCAGCCCGTGAAGATTTGGCGCAGGTTATGACTAAAGTTTGTGAAGACCAAGTAGT
AACACATATTACGCGTCGGAACGGAGGGAACTGTGTCTTGATGTCTGAGGAAGAGTACAGCTCTATTATGGAGACACTTT
ACCTGTTCGGAAATCCTACTAATGCTGCACGTTTGGAACACTCGCTGGCTCAAGCAGAACAGGGAGAATTTGTAGAGGTT
GATCTGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9334.61 Da        Isoelectric Point: 4.7954

>AT164722 WP_128880351.1 NZ_CP057093:1827273-1827524 [Escherichia fergusonii]
MRTINYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT164722 NZ_CP073115:2199724-2199987 [Neisseria subflava]
GTGAGGAAGCACCGTTTTACCGCTGATGCCGCCGAAGATTTGGCATATTGGAAAAAACATGATGCTAGGAAGGTTGAACG
GATTAAGTTGCTTTTGGAAGATATTAAAGCCAACCATCCGAAGGGAATCGGTAAACCTGAACCACTTCGTCACCATAAAT
CGGGCTTATGGTCGCGAAGGATTGATCGGGAACACCGTTTGGTTTATTCGGTAGATGAAGATACGGTAACTGTATATGCT
TGCCGATACCATTACGAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References