Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 754767..755025 Replicon chromosome
Accession NZ_CP057093
Organism Escherichia fergusonii strain RHB38-C07

Toxin (Protein)


Gene name hokC Uniprot ID -
Locus tag HVZ69_RS03780 Protein ID WP_000935262.1
Coordinates 754767..754976 (-) Length 70 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 754968..755025 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ69_RS03760 749833..750420 + 588 WP_002431696.1 molybdopterin adenylyltransferase -
HVZ69_RS03765 750454..751020 - 567 WP_000528529.1 acetate uptake transporter -
HVZ69_RS03770 751528..753444 + 1917 WP_000516135.1 molecular chaperone DnaK -
HVZ69_RS03775 753533..754663 + 1131 WP_001118464.1 molecular chaperone DnaJ -
HVZ69_RS03780 754767..754976 - 210 WP_000935262.1 type I toxin-antitoxin system Hok family toxin Toxin
- 754968..755025 + 58 - - Antitoxin
HVZ69_RS03785 755460..756626 + 1167 WP_181588343.1 Na+/H+ antiporter NhaA -
HVZ69_RS03790 756694..757593 + 900 WP_181588344.1 transcriptional activator NhaR -
HVZ69_RS03795 757689..757952 - 264 WP_001274021.1 30S ribosomal protein S20 -
HVZ69_RS03800 758055..758273 + 219 WP_001300728.1 DUF2575 family protein -
HVZ69_RS03805 758281..759222 + 942 WP_000767329.1 bifunctional riboflavin kinase/FAD synthetase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(25-66)


Sequences


Toxin        


Download         Length: 70 a.a.        Molecular weight: 7742.28 Da        Isoelectric Point: 9.3680

>T164718 WP_000935262.1 NZ_CP057093:c754976-754767 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 210 bp

>T164718 NZ_CP073110:3786996-3787241 [Agrobacterium rhizogenes]
ATGAGACAGTTTCTGCAGCCCAAGAATGCTGCCTCCGCAAAGAAAGCTTCGACAAAGATCATTCAAACGATCCAGATGTT
GTCGAACCAGCCCGATATGGGTCGGCCAGTGGAAGACTTGCATCAAGGATTGAGGGAGCTCATCGTCAAATTCGGGCGCG
ACGGTTACGTTGTTCTCTACCGGTATATTGGCGATGAAGTGCTCATAGCGGCTATCCGCCATGGTCGTGAAGACGGATAC
AAGTAA

Antitoxin


Download         Length: 58 bp

>AT164718 NZ_CP057093:754968-755025 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References