Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 324347..324933 Replicon chromosome
Accession NZ_CP057066
Organism Klebsiella pneumoniae strain RHB39-C10

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag HVZ82_RS01510 Protein ID WP_002920800.1
Coordinates 324565..324933 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag HVZ82_RS01505 Protein ID WP_004174006.1
Coordinates 324347..324568 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ82_RS01485 320504..321430 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
HVZ82_RS01490 321427..322704 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
HVZ82_RS01495 322701..323468 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HVZ82_RS01500 323470..324183 + 714 WP_009484078.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
HVZ82_RS01505 324347..324568 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HVZ82_RS01510 324565..324933 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HVZ82_RS01515 325206..326522 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
HVZ82_RS01520 326629..327516 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
HVZ82_RS01525 327513..328358 + 846 WP_065801119.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
HVZ82_RS01530 328360..329430 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 321427..330167 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T164672 WP_002920800.1 NZ_CP057066:324565-324933 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T164672 NZ_CP073061:c60524-60234 [Acinetobacter baumannii]
ATGGTTAAAGTAGCTGATTTACCAAGTTTTGATATGGCTGAGTCACTCAAAACTGAAGAAGACATCGTGATGTATCTCAA
TATGGTTCTTGAAGATAATGATCCTGCTGAATTAGCTCATGCCCTTGGTGTCATTGCTAAAGCTAGAGGTATGACCCAAA
TTGCTAAAGAAGCAGGGATCGGACGTGAAGCACTTTATAAAGCACTTCGCCATGATTCAGCTCCGCGTTTTGATACTATC
AATCGTGTTGTGAATGCACTTGGCTTAAAATTAACAGTTCAGCATACATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT164672 WP_004174006.1 NZ_CP057066:324347-324568 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT164672 NZ_CP073061:c60822-60526 [Acinetobacter baumannii]
ATGATTGAAATTAAACGTCTACCAGAATTTGATGAATGGTTGGATGGCATTAAAGACAATATGACCCGCATTCGCTTGAA
TCGCCGATTAGATAAGGTTCAACGCGGGAACTGGGGAGACATTAAACCTCTCCAAGATGGCGTTTGGGAAATGAGAGAAT
TCTTCGGTTCTGGATGGAGGATGTATTACATCCAACATGGTGACGTTGTGATTGTAATGCTTGGTGGTGGAGATAAATCA
ACTCAACAACAAGACATCGATCGTGCAGTCAAATTATCGAAAACGTTGGAGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References