Detailed information of TA system TA164648

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4441048..4441305
• Replicon: chromosome
• Accession: NZ_CP056968
• Organism: Escherichia fergusonii strain RHB41-C15

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: F4T5C6
• Locus tag: HV010_RS21550
• Protein ID: WP_001135731.1
• Coordinates: 4441048..4441200 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4441257..4441305 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV010_RS21525	4436242..4437216	+	975	WP_181588062.1	glyoxylate/hydroxypyruvate reductase GhrB	-
HV010_RS21530	4437309..4438019	-	711	WP_181588063.1	DUF3053 domain-containing protein	-
HV010_RS21535	4438457..4439827	+	1371	WP_181588064.1	MFS transporter	-
HV010_RS21540	4440077..4440367	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HV010_RS21545	4440648..4440860	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HV010_RS21550	4441048..4441200	-	153	WP_001135731.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4441257..4441305	+	49	-	-	Antitoxin
HV010_RS21555	4441522..4443591	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
HV010_RS21560	4443601..4444512	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HV010_RS21565	4444608..4444907	-	300	WP_024256552.1	YsaB family lipoprotein	-
HV010_RS21570	4445079..4446074	+	996	WP_181588065.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 6025.30 Da
• Isoelectric Point: 7.7169

>T164648 WP_001135731.1 NZ_CP056968:c4441200-4441048 [Escherichia fergusonii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T164648 NZ_CP073013:2055453-2055776 [Marinomonas profundi]
ATGACTTGGAAGATAGACATTTATGATGGTGTGGAAGATCAAATTCTTCAAATGCCACCCAAAATCCAATCGAGGATGAT
TAAACTATTAGAGCTGATGGAGAAGCATGGCGCTAATTTAGGGCCGCCTCATACAGATTCTATGGGTAACGGATTATTCG
AGATTAGGGCGAAAGCTCAAGAAGGCATTGGCCGTAGTTTGTTTTGTTACTTAAAAGGGAAGCATATTTATATCTTGCAT
GCCTTTGTTAAAAAGTCACAAAAAACGCCTAAAAATGAGCTGGAGCTTGCACGTCAACGCCAGAAAGAGGTTCAAAAAAG
ATGA

Antitoxin

Nucleotide

• Length: 49 bp

>AT164648 NZ_CP056968:4441257-4441305 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A061YDD9

Antitoxin