Detailed information of TA system TA164621

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 742989..743247
• Replicon: chromosome
• Accession: NZ_CP056968
• Organism: Escherichia fergusonii strain RHB41-C15

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HV010_RS03710
• Protein ID: WP_000935262.1
• Coordinates: 742989..743198 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	743190..743247 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV010_RS03690	738055..738642	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HV010_RS03695	738676..739242	-	567	WP_000528529.1	acetate uptake transporter	-
HV010_RS03700	739750..741666	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HV010_RS03705	741755..742885	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HV010_RS03710	742989..743198	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	743190..743247	+	58	-	-	Antitoxin
HV010_RS03715	743682..744848	+	1167	WP_181588343.1	Na+/H+ antiporter NhaA	-
HV010_RS03720	744916..745815	+	900	WP_181588344.1	transcriptional activator NhaR	-
HV010_RS03725	745911..746174	-	264	WP_001274021.1	30S ribosomal protein S20	-
HV010_RS03730	746277..746495	+	219	WP_001300728.1	DUF2575 family protein	-
HV010_RS03735	746503..747444	+	942	WP_000767329.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T164621 WP_000935262.1 NZ_CP056968:c743198-742989 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T164621 NZ_CP073002:875742-876149 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT164621 NZ_CP056968:743190-743247 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin