Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 308232..308898 Replicon chromosome
Accession NZ_CP056967
Organism Citrobacter freundii strain RHB41-C16

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV011_RS01455 Protein ID WP_117342464.1
Coordinates 308581..308898 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4U6IRD5
Locus tag HV011_RS01450 Protein ID WP_003837894.1
Coordinates 308232..308528 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV011_RS01435 305408..305881 - 474 WP_003023524.1 transcription elongation factor GreB -
HV011_RS01440 306108..306827 + 720 WP_001157751.1 two-component system response regulator OmpR -
HV011_RS01445 306824..308176 + 1353 WP_096759268.1 two-component system sensor histidine kinase EnvZ -
HV011_RS01450 308232..308528 - 297 WP_003837894.1 helix-turn-helix domain-containing protein Antitoxin
HV011_RS01455 308581..308898 - 318 WP_117342464.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV011_RS01460 309022..310644 - 1623 WP_115257300.1 phosphoenolpyruvate carboxykinase (ATP) -
HV011_RS01465 311023..312741 + 1719 WP_181596153.1 DUF4153 domain-containing protein -
HV011_RS01470 312792..313670 - 879 WP_096759272.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12226.13 Da        Isoelectric Point: 9.8310

>T164600 WP_117342464.1 NZ_CP056967:c308898-308581 [Citrobacter freundii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSDMLI

Download         Length: 318 bp

>T164600 NZ_CP072990:c3932821-3932669 [Xanthomonas translucens pv. translucens]
ATGAAGCGACTGTTCACCTTGACGATGCTGACCCTGTTTTGTGCAGGCATGCTGACCGGCTGCAACACCATGGCCGGCGC
CGGTAAGGACATGCAGAAGGCCGGCGATAAGGTGGAAACCAAGGCCGACGACTGTAAAGACGGCAAGTGCTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.93 Da        Isoelectric Point: 7.2050

>AT164600 WP_003837894.1 NZ_CP056967:c308528-308232 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp

>AT164600 NZ_CP072990:c3932570-3932436 [Xanthomonas translucens pv. translucens]
ATGAAGCGTACTTTCGCGTGGATGCTGCTGGCGATGTTCTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U6IRD5

References