Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1815495..1815997 Replicon chromosome
Accession NZ_CP056961
Organism Escherichia fergusonii strain RHB41-C20

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HV012_RS08690 Protein ID WP_000767829.1
Coordinates 1815743..1815997 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HV012_RS08685 Protein ID WP_128880351.1
Coordinates 1815495..1815746 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV012_RS08660 1810672..1811739 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HV012_RS08665 1811739..1812809 - 1071 WP_138957225.1 histidinol-phosphate transaminase -
HV012_RS08670 1812806..1814110 - 1305 WP_181588649.1 histidinol dehydrogenase -
HV012_RS08675 1814116..1815015 - 900 WP_000131779.1 ATP phosphoribosyltransferase -
HV012_RS08680 1815161..1815211 - 51 WP_001364200.1 his operon leader peptide -
HV012_RS08685 1815495..1815746 + 252 WP_128880351.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HV012_RS08690 1815743..1815997 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HV012_RS08695 1816080..1816904 + 825 WP_000754745.1 SDR family oxidoreductase -
HV012_RS08700 1816950..1817879 + 930 WP_181588650.1 LysR family transcriptional regulator -
HV012_RS08705 1818094..1818156 + 63 WP_010723108.1 membrane protein YoeI -
HV012_RS08710 1818146..1819504 + 1359 WP_000019201.1 putrescine/proton symporter PlaP -
HV012_RS08715 1819683..1820741 + 1059 WP_046080827.1 transport protein YeeE -
HV012_RS08720 1820755..1820982 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T164573 WP_000767829.1 NZ_CP056961:1815743-1815997 [Escherichia fergusonii]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T164573 NZ_CP072986:1794774-1795028 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9334.61 Da        Isoelectric Point: 4.7954

>AT164573 WP_128880351.1 NZ_CP056961:1815495-1815746 [Escherichia fergusonii]
MRTINYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT164573 NZ_CP072986:1794526-1794777 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References