Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2544097..2544757 Replicon chromosome
Accession NZ_CP056936
Organism Escherichia fergusonii strain RHB42-C13

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV020_RS12225 Protein ID WP_046077353.1
Coordinates 2544404..2544757 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV020_RS12220 Protein ID WP_001553123.1
Coordinates 2544097..2544399 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV020_RS12200 2539456..2540253 + 798 WP_046077351.1 DgsA anti-repressor MtfA -
HV020_RS12210 2540591..2541852 + 1262 Protein_2380 integrase arm-type DNA-binding domain-containing protein -
HV020_RS12215 2542709..2543593 - 885 WP_046077352.1 integrase domain-containing protein -
HV020_RS12220 2544097..2544399 - 303 WP_001553123.1 XRE family transcriptional regulator Antitoxin
HV020_RS12225 2544404..2544757 - 354 WP_046077353.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV020_RS12230 2545254..2545475 - 222 WP_046077354.1 helix-turn-helix domain-containing protein -
HV020_RS12235 2545472..2545939 - 468 WP_046077355.1 hypothetical protein -
HV020_RS12240 2546826..2547605 + 780 WP_046077393.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13486.42 Da        Isoelectric Point: 8.9507

>T164533 WP_046077353.1 NZ_CP056936:c2544757-2544404 [Escherichia fergusonii]
VWTIKTTDMFDHWFISLNDTDRASVLAALLVLREKGPGLSRPYADTIRGSRYSNMKELRIQSRGDPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPIADREFTNWLNTLKEKE

Download         Length: 354 bp

>T164533 NZ_CP072976:4764748-4764855 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11084.82 Da        Isoelectric Point: 5.1786

>AT164533 WP_001553123.1 NZ_CP056936:c2544399-2544097 [Escherichia fergusonii]
MGRTLEQLIADEKPEVVDEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp

>AT164533 NZ_CP072976:c4764701-4764635 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References