Detailed information of TA system TA164522

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 572768..573026
• Replicon: chromosome
• Accession: NZ_CP056936
• Organism: Escherichia fergusonii strain RHB42-C13

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HV020_RS02890
• Protein ID: WP_000935262.1
• Coordinates: 572768..572977 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	572969..573026 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV020_RS02870	567834..568421	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HV020_RS02875	568455..569021	-	567	WP_000528529.1	acetate uptake transporter	-
HV020_RS02880	569529..571445	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HV020_RS02885	571534..572664	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HV020_RS02890	572768..572977	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	572969..573026	+	58	-	-	Antitoxin
HV020_RS02895	573461..574627	+	1167	WP_046076806.1	Na+/H+ antiporter NhaA	-
HV020_RS02900	574695..575594	+	900	WP_000019050.1	transcriptional activator NhaR	-
HV020_RS02905	575690..575953	-	264	WP_001274021.1	30S ribosomal protein S20	-
HV020_RS02910	576056..576274	+	219	WP_046076805.1	DUF2575 family protein	-
HV020_RS02915	576282..577223	+	942	WP_046076804.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T164522 WP_000935262.1 NZ_CP056936:c572977-572768 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T164522 NZ_CP072976:c2715397-2714933 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT164522 NZ_CP056936:572969-573026 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin