Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4933919..4934589 Replicon chromosome
Accession NZ_CP056907
Organism Citrobacter freundii strain RHBSTW-00011

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV032_RS23515 Protein ID WP_075145335.1
Coordinates 4934287..4934589 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV032_RS23510 Protein ID WP_043018115.1
Coordinates 4933919..4934260 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV032_RS23480 4929400..4930158 + 759 WP_003826710.1 phosphonate C-P lyase system protein PhnK -
HV032_RS23485 4930302..4930988 + 687 WP_043018513.1 phosphonate C-P lyase system protein PhnL -
HV032_RS23490 4930985..4932121 + 1137 WP_181634146.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
HV032_RS23495 4932124..4932678 + 555 WP_043018118.1 ribose 1,5-bisphosphokinase -
HV032_RS23500 4932665..4933099 + 435 WP_043018117.1 aminoalkylphosphonate N-acetyltransferase -
HV032_RS23505 4933108..4933866 + 759 WP_043018116.1 phosphonate metabolism protein PhnP -
HV032_RS23510 4933919..4934260 - 342 WP_043018115.1 HigA family addiction module antidote protein Antitoxin
HV032_RS23515 4934287..4934589 - 303 WP_075145335.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV032_RS23520 4934746..4935075 - 330 WP_181634147.1 hypothetical protein -
HV032_RS23525 4935145..4937409 - 2265 WP_181634148.1 hybrid sensor histidine kinase/response regulator -
HV032_RS23530 4937524..4939047 + 1524 WP_075145337.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11833.46 Da        Isoelectric Point: 9.9581

>T164466 WP_075145335.1 NZ_CP056907:c4934589-4934287 [Citrobacter freundii]
MSKSLNIRSFRDTWLEDFFERATSHRKIPADIHTALARKLDIINAAVSHRDLRSPPGNRYEELTGKLQEYSSIRVNKQYR
LIFKWINGKAEDVYLDPHIY

Download         Length: 303 bp

>T164466 NZ_CP072945:c3962165-3961755 [Enterobacter sp. MGH 7]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTGGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCAA
CGCAGGAATAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13075.88 Da        Isoelectric Point: 6.4763

>AT164466 WP_043018115.1 NZ_CP056907:c4934260-4933919 [Citrobacter freundii]
MKQATRKPTTVGDILQYEYLEPLELKINDLAEILHVHRNTVSALVNNNRKLTTDMAFRLAKAFDTSVDFWRNLQSAVDLW
EVENDMRAQEELNRIVSVKDFIAQRNGESKKVA

Download         Length: 342 bp

>AT164466 NZ_CP072945:c3962412-3962146 [Enterobacter sp. MGH 7]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References