164231

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2800546..2801779 Replicon chromosome
Accession NZ_CP056783
Organism Flavobacterium sp. K5-23

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag FLAK523_RS12175 Protein ID WP_248903783.1
Coordinates 2800546..2801472 (-) Length 309 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag FLAK523_RS12180 Protein ID WP_248903786.1
Coordinates 2801465..2801779 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLAK523_RS12155 (FLAK523_12125) 2795849..2798725 + 2877 WP_248903774.1 type I restriction endonuclease subunit R -
FLAK523_RS12160 (FLAK523_12130) 2799014..2799538 + 525 WP_248903776.1 hypothetical protein -
FLAK523_RS12165 (FLAK523_12135) 2799541..2800017 + 477 WP_248903778.1 helix-turn-helix transcriptional regulator -
FLAK523_RS12170 (FLAK523_12140) 2800017..2800475 + 459 WP_248903780.1 hypothetical protein -
FLAK523_RS12175 (FLAK523_12145) 2800546..2801472 - 927 WP_248903783.1 HipA domain-containing protein Toxin
FLAK523_RS12180 (FLAK523_12150) 2801465..2801779 - 315 WP_248903786.1 HipA N-terminal domain-containing protein Antitoxin
FLAK523_RS12185 (FLAK523_12155) 2801782..2801991 - 210 WP_248903788.1 helix-turn-helix transcriptional regulator -
FLAK523_RS12190 (FLAK523_12160) 2802261..2802572 + 312 WP_248903789.1 type II toxin-antitoxin system HigB family toxin -
FLAK523_RS12195 (FLAK523_12165) 2802592..2802948 + 357 WP_248903791.1 helix-turn-helix domain-containing protein -
FLAK523_RS12200 (FLAK523_12170) 2803218..2803895 - 678 WP_248903793.1 2OG-Fe(II) oxygenase -
FLAK523_RS12205 (FLAK523_12175) 2804082..2805224 + 1143 WP_248903795.1 saccharopine dehydrogenase C-terminal domain-containing protein -
FLAK523_RS12210 (FLAK523_12180) 2805332..2806051 + 720 WP_248903805.1 DUF4339 domain-containing protein -
FLAK523_RS12215 (FLAK523_12185) 2806124..2806507 - 384 WP_248903807.1 YchJ family metal-binding protein -
FLAK523_RS12220 (FLAK523_12190) 2806537..2806761 - 225 WP_248903809.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(52-277)

Antitoxin

HipA, N-terminal subdomain 1

(4-98)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 35479.09 Da        Isoelectric Point: 8.8850

>T164231 WP_248903783.1 NZ_CP056783:c2801472-2800546 [Flavobacterium sp. K5-23]
MNRCPITYDLCGTDKYSEKGLRMIAPKLTYLNDLPYTAVELRQEAANRAKKLSIQGVQPKLSAAISIVDQEFKIVDQFGT
YIIKPQNDLFPQLPENEDVTMRMAKVFGLEVPFHGMLYGKDGSLSYFIKRFDRYGKGSKFATEDFAQLTGNTRDTKYRFT
MEKLIPVLDEYCSFPAIEKADFFKRILFCFVTGNEDMHLKNFSLITKNGKTTLTPIYDFLNSTISIKNPEEEIALTLKGK
KSNLKAADFVDYYAKERLQLNEKTIANILQQIKKATPKWKELLEISFLSDDMKGKYFDLLEARLEVFK

Download         Length: 927 bp

>T164231 NZ_CP072848:419196-419597 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11721.35 Da        Isoelectric Point: 4.8380

>AT164231 WP_248903786.1 NZ_CP056783:c2801779-2801465 [Flavobacterium sp. K5-23]
MRRAIVFAHGKRAGILTEIAANDYHFEYNENYDGEAVSLTMPTSHNKYSYTSFPPFFEGLLPEGVMLEGLLRIVKIDKKD
YFSQLIATGNDLVGAVTVKLMEDE

Download         Length: 315 bp

>AT164231 NZ_CP072848:419026-419196 [Vibrio cholerae]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References