Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3928975..3929632 Replicon chromosome
Accession NZ_CP056779
Organism Enterobacter cloacae strain D41-sc-1712200

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HWQ17_RS18820 Protein ID WP_148421423.1
Coordinates 3929333..3929632 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HWQ17_RS18815 Protein ID WP_148421421.1
Coordinates 3928975..3929322 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ17_RS18785 3924144..3924878 + 735 WP_148421409.1 class I SAM-dependent methyltransferase -
HWQ17_RS18790 3924872..3925474 - 603 WP_148421411.1 short chain dehydrogenase -
HWQ17_RS18795 3925573..3926460 + 888 WP_148421413.1 LysR family transcriptional regulator -
HWQ17_RS18800 3926481..3927662 + 1182 WP_148421415.1 PLP-dependent aminotransferase family protein -
HWQ17_RS18805 3927717..3928136 - 420 WP_148421417.1 nuclear transport factor 2 family protein -
HWQ17_RS18810 3928232..3928960 + 729 WP_148421419.1 helix-turn-helix transcriptional regulator -
HWQ17_RS18815 3928975..3929322 - 348 WP_148421421.1 HigA family addiction module antidote protein Antitoxin
HWQ17_RS18820 3929333..3929632 - 300 WP_148421423.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HWQ17_RS18825 3929881..3931041 - 1161 WP_148421525.1 HlyD family efflux transporter periplasmic adaptor subunit -
HWQ17_RS18830 3931061..3933253 - 2193 WP_148421425.1 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11662.32 Da        Isoelectric Point: 9.8985

>T164220 WP_148421423.1 NZ_CP056779:c3929632-3929333 [Enterobacter cloacae]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAKSHLDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
SEGKAEDLYLSPHKYTQHK

Download         Length: 300 bp

>T164220 NZ_CP072846:c4266920-4266549 [Brevibacterium oceani]
ATGATCCTTGTCGACACCTCGGTGTGGATCGACCATCTTCATCGACCCGATCCTCTGCTCCAGCGTCTGCTGGAGGTCGA
TGAGGTCGGATGCCACTCCGCGGTCGTCGAAGAATTGGGTCTCGGTACGCTGAAGTCTCGCAACGACTTTCTCAACGACC
TCGAATCGCTGTTCAGGTTTCCCGTTCTGGCTCACGATGAGCTCATGAGCTTCATCGCGATGCGGTCGCTATGGGGTCGA
GGGCTGAGCGCGGCCGACGTCCACCTTCTCGGTTCCGTGTTGGTGATCGACGGTGCTCGTCTGTGGACACGCGATAAGAG
ACTGCTGCGCGCTGCCGAAGAGGTCGGCTGCGCTTTCGTTCACGACGAGTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13039.04 Da        Isoelectric Point: 9.5932

>AT164220 WP_148421421.1 NZ_CP056779:c3929322-3928975 [Enterobacter cloacae]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFGTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT164220 NZ_CP072846:c4267114-4266917 [Brevibacterium oceani]
ATGCGAACCACAGTCACCATCGATGATGAGCTCATGGACAAAGCCGCGGAGATCAGCGGAATCACTGAGCGCTCGGCCCT
GATCCGCGAGGCTCTCAAGACACTTGTCAGGGTGGAGAGTGCGCGACGCCTTGCGGCTCTTGGAGGTTCTGATCCGGAGA
GTTCCGCGGCACTCCGACGGCGTAACGAAGTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References