Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1866057..1866659 Replicon chromosome
Accession NZ_CP056776
Organism Enterobacter cloacae strain DSM 30054

Toxin (Protein)


Gene name higB Uniprot ID A0A5E1AN02
Locus tag HWQ16_RS09020 Protein ID WP_013099360.1
Coordinates 1866057..1866368 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HWQ16_RS09025 Protein ID WP_013099359.1
Coordinates 1866369..1866659 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ16_RS08990 1861083..1861883 + 801 WP_013099366.1 DeoR/GlpR family DNA-binding transcription regulator -
HWQ16_RS08995 1862003..1862602 + 600 WP_013099365.1 glucose-1-phosphatase -
HWQ16_RS09000 1862596..1863477 + 882 WP_013099364.1 virulence factor BrkB family protein -
HWQ16_RS09005 1863474..1863911 + 438 WP_013099363.1 D-tyrosyl-tRNA(Tyr) deacylase -
HWQ16_RS09010 1863956..1864897 + 942 WP_013099362.1 fatty acid biosynthesis protein FabY -
HWQ16_RS09015 1864910..1865827 - 918 WP_013099361.1 alpha/beta hydrolase -
HWQ16_RS09020 1866057..1866368 + 312 WP_013099360.1 hypothetical protein Toxin
HWQ16_RS09025 1866369..1866659 + 291 WP_013099359.1 helix-turn-helix domain-containing protein Antitoxin
HWQ16_RS09030 1866702..1867631 - 930 WP_013099358.1 formate dehydrogenase accessory protein FdhE -
HWQ16_RS09035 1867628..1868263 - 636 WP_013099357.1 formate dehydrogenase cytochrome b556 subunit -
HWQ16_RS09040 1868260..1869162 - 903 WP_013099356.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12210.18 Da        Isoelectric Point: 9.7550

>T164197 WP_013099360.1 NZ_CP056776:1866057-1866368 [Enterobacter cloacae]
MLFIETDIFTEDVKTLLDDDEYHKLQVFLATQPDYGDLIQNTGGLRKIRWLSGGRGKRGGVRVIYFHRTHEFEIRLLLIY
RKGIKDDLSAREKAILKKMIERW

Download         Length: 312 bp

>T164197 NZ_CP072826:2901207-2901309 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10623.13 Da        Isoelectric Point: 10.4747

>AT164197 WP_013099359.1 NZ_CP056776:1866369-1866659 [Enterobacter cloacae]
MDKALFERLTQSIAQMDDIVGGKREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVISALSD

Download         Length: 291 bp

>AT164197 NZ_CP072826:c2901316-2901171 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AN02

Antitoxin

Source ID Structure

References