164182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 19015..19610 Replicon chromosome
Accession NZ_CP056774
Organism Pseudomonas aeruginosa strain CDN129

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag HWH78_RS00080 Protein ID WP_003113526.1
Coordinates 19015..19293 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HWH78_RS00085 Protein ID WP_003113527.1
Coordinates 19305..19610 (+) Length 102 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWH78_RS00065 14441..15679 + 1239 WP_033942304.1 C69 family dipeptidase -
HWH78_RS00070 15741..16388 + 648 WP_003095021.1 carbonate dehydratase -
HWH78_RS00075 16458..18686 - 2229 WP_033942306.1 TonB-dependent receptor -
HWH78_RS00080 19015..19293 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HWH78_RS00085 19305..19610 + 306 WP_003113527.1 HigA family addiction module antidote protein Antitoxin
HWH78_RS00095 20005..21105 - 1101 WP_033942321.1 redox-regulated ATPase YchF -
HWH78_RS00100 21146..21730 - 585 WP_033942324.1 aminoacyl-tRNA hydrolase -
HWH78_RS00105 21772..22386 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
HWH78_RS00110 22503..23444 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
HWH78_RS00120 23611..24459 - 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-92)

Antitoxin

(22-69)


Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T164182 WP_003113526.1 NZ_CP056774:19015-19293 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T164182 NZ_CP072825:3005214-3005582 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT164182 WP_003113527.1 NZ_CP056774:19305-19610 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT164182 NZ_CP072825:3004996-3005217 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V6ALY3


Antitoxin

Source ID Structure

References