Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2014169..2014829 Replicon chromosome
Accession NZ_CP056760
Organism Klebsiella grimontii strain RHBSTW-00186

Toxin (Protein)


Gene name higB Uniprot ID A0A9E1DE76
Locus tag HV114_RS09525 Protein ID WP_064342919.1
Coordinates 2014169..2014522 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1DQ94
Locus tag HV114_RS09530 Protein ID WP_004132739.1
Coordinates 2014527..2014829 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV114_RS09500 2009553..2010320 - 768 WP_064342921.1 molybdopterin-dependent oxidoreductase -
HV114_RS09505 2010310..2010918 - 609 WP_004132729.1 cytochrome b/b6 domain-containing protein -
HV114_RS09510 2010933..2011559 - 627 WP_004132731.1 hypothetical protein -
HV114_RS09515 2011699..2012367 + 669 WP_004132733.1 heavy metal response regulator transcription factor -
HV114_RS09520 2012367..2013785 + 1419 WP_064342920.1 heavy metal sensor histidine kinase -
HV114_RS09525 2014169..2014522 + 354 WP_064342919.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV114_RS09530 2014527..2014829 + 303 WP_004132739.1 XRE family transcriptional regulator Antitoxin
HV114_RS09535 2015023..2015226 + 204 Protein_1869 hypothetical protein -
HV114_RS09540 2015227..2015559 + 333 WP_064342918.1 type II toxin-antitoxin system PemK/MazF family toxin -
HV114_RS09550 2015883..2017340 + 1458 WP_004136541.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
HV114_RS09560 2018368..2019822 - 1455 WP_024359975.1 AMP nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13623.60 Da        Isoelectric Point: 10.2537

>T164168 WP_064342919.1 NZ_CP056760:2014169-2014522 [Klebsiella grimontii]
VWMIKTTDTFERWFTSFNDTDRARVLAALLVLREKGPGLSRPNADTLRGSRYSNMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKEKE

Download         Length: 354 bp

>T164168 NZ_CP072802:3749050-3749430 [Escherichia coli]
ATGCAAACACAATCCCACTCCCCGGAGCGGGCAGCCCGGACCTGCCCGTCACCCGTTGAAATCTGGCAGCAGCTTCTCAC
GCATCTGCTGGACCAGCACTACGGCCTCACGCTGAACGATACCCCATTTGGCAACGCTGGCGTCATTCAGGAACACATTA
GCGCCGGTATCTCCCTGTGCGACGCCGTGAATTTTATCGTCGAAAAATATGACCTTGTGCGCACTGACCGTCGCGGTTTC
TCCGTGGCGGAGCAATCACCATTAATCAGCAGTATCGATATACTTCGCGCCCGACGTGCCACCGGGCTGATGAAACGTCA
GGGCTACAGAGCCGTTACCGATATCACCACCGGGCAATATTCACAGGAGTCCGGGCAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11072.83 Da        Isoelectric Point: 5.7424

>AT164168 WP_004132739.1 NZ_CP056760:2014527-2014829 [Klebsiella grimontii]
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL

Download         Length: 303 bp

>AT164168 NZ_CP072802:3748640-3748999 [Escherichia coli]
ATGCCAAAAACACCCAACGATACAAACCATGATATCGCTGAGCCCTGGTGGGGCCTGCAACGCAACGTCACTCCGTGCTT
TGGAGCCAGACTGGTGCAGGAGGGCAACCGGCTGCATTACCTGGCCGACCGCGCCAGTATCACTGGCACCTTCAGCGAGG
CGGGTTTACGTCATCTCGACCAGGCTTTCCCTGTATTGCTCAAACAACTGGAGATGATGCTCACCTGCGGTGAACTTAGC
CCGCACCACCAGCACTGTGTCACGCTGTATGAGAAAGGGCTGACATGCGACGCTGACACCCTCGGCTCGCATGGATACGT
GTATATGGCTATTTATCCGACACCCTCAACAACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References