164162

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2959870..2960530 Replicon chromosome
Accession NZ_CP056756
Organism Enterobacter hormaechei strain RHBSTW-00198

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV117_RS14455 Protein ID WP_047053529.1
Coordinates 2960177..2960530 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0Q4Z7
Locus tag HV117_RS14450 Protein ID WP_017383313.1
Coordinates 2959870..2960172 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV117_RS14435 2956040..2957365 + 1326 WP_047053533.1 SidA/IucD/PvdA family monooxygenase -
HV117_RS14440 2957392..2959581 + 2190 WP_047053531.1 TonB-dependent siderophore receptor -
HV117_RS14450 2959870..2960172 - 303 WP_017383313.1 helix-turn-helix transcriptional regulator Antitoxin
HV117_RS14455 2960177..2960530 - 354 WP_047053529.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV117_RS14460 2960721..2961671 - 951 WP_003859532.1 HTH-type transcriptional regulator Cbl -
HV117_RS14465 2961768..2962685 - 918 WP_003859531.1 nitrogen assimilation transcriptional regulator NAC -
HV117_RS14475 2963174..2964097 - 924 WP_047053526.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13522.40 Da        Isoelectric Point: 10.1729

>T164162 WP_047053529.1 NZ_CP056756:c2960530-2960177 [Enterobacter hormaechei]
VWAIKTTDRFDDWFTSLNDSERASVLAALLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFNPNRTGI
VLCAGNKIGNERRFYDEMLLVADREYTRWLNTLKERN

Download         Length: 354 bp

>T164162 NZ_CP072802:3225448-3225555 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11028.85 Da        Isoelectric Point: 6.4727

>AT164162 WP_017383313.1 NZ_CP056756:c2960172-2959870 [Enterobacter hormaechei]
MGRTLEQLIADEKPEVVASAQAMATDILLNIHLAELREKVQKTQVDMARALGIKQPTVAVMEKAGRDIKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT164162 NZ_CP072802:c3225391-3225334 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0Q4Z7

References