Detailed information of TA system TA164145

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 66159..66661
• Replicon: chromosome
• Accession: NZ_CP056756
• Organism: Enterobacter hormaechei strain RHBSTW-00198

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HV117_RS00365
• Protein ID: WP_047050704.1
• Coordinates: 66159..66413 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HV117_RS00370
• Protein ID: WP_047050702.1
• Coordinates: 66410..66661 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV117_RS00335	61623..62147	-	525	WP_047050709.1	lipocalin family protein	-
HV117_RS00340	62265..62990	+	726	WP_017383646.1	MerR family transcriptional regulator	-
HV117_RS00345	63090..63500	+	411	WP_022650126.1	hydroxyisourate hydrolase	-
HV117_RS00350	63603..64562	+	960	WP_047050707.1	DUF523 and DUF1722 domain-containing protein	-
HV117_RS00355	64709..65797	+	1089	WP_047050706.1	AAA family ATPase	-
HV117_RS00360	65928..66083	-	156	WP_154815872.1	hypothetical protein	-
HV117_RS00365	66159..66413	-	255	WP_047050704.1	Txe/YoeB family addiction module toxin	Toxin
HV117_RS00370	66410..66661	-	252	WP_047050702.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
HV117_RS00375	66912..68162	-	1251	WP_047050701.1	HlyD family efflux transporter periplasmic adaptor subunit	-
HV117_RS00380	68169..68918	-	750	WP_047050700.1	hypothetical protein	-
HV117_RS00385	68915..71011	-	2097	WP_047050699.1	peptidase domain-containing ABC transporter	-
HV117_RS00390	71079..71264	-	186	WP_063159820.1	hypothetical protein	-
HV117_RS00395	71288..71482	-	195	WP_000644465.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	45104..66661	21557

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10117.66 Da
• Isoelectric Point: 7.8747

>T164145 WP_047050704.1 NZ_CP056756:c66413-66159 [Enterobacter hormaechei]
VKITWSEEAWEDYLYWQETDKRMVRKINELIKISCRTPFEGIGKPEPLKHNLAGFWSRRITSEHRMVYAITEEAILIAAC
RYHY

Nucleotide

• Length: 255 bp

>T164145 NZ_CP072801:2274288-2274704 [Thiothrix litoralis]
ATGTATTTGCTTGATACCAATGTCATCAGCGAAATCCGCAAGGGACAACGCGCCAATCCGGGTGTGCAAGCATTTTTCCA
ACACGTTACCCACAACCACGACAAGCTCTTTCTCTCTGCGGTAACGATTGGGGAATTGCGGCGGGGAATTGAACTGATCC
GTTACCGTAACGATCATGTGCAGGCGCACCAACTGGAACAATGGTTGGAACAAATCCTAAGCGACTATCAAGACCATATA
ATCGGGCTGGATGCTGATGCAGCACAACTGTGGGGACGGTTGCGTGTCCCCCATCATGAACACGAGCTGGATAAGCTGAT
TGCGGCGAGTGCCTTGCTCTATGATTTGACGGTAGTAACTCGCAATGTGGATGACTTCGCGGGGACAAGCGTTAAGCTGC
TGAACCCGTTTACTTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9343.57 Da
• Isoelectric Point: 4.7854

>AT164145 WP_047050702.1 NZ_CP056756:c66661-66410 [Enterobacter hormaechei]
MRVISYSEARQNLSATMVQTTEDRAPVLITRQNGESCVLMSLEEYNSLEETAYLMRSPANAKRLMNSIESLKSGSGKERD
IIE

Nucleotide

• Length: 252 bp

>AT164145 NZ_CP072801:2274065-2274301 [Thiothrix litoralis]
ATGTCAAACTTGATTGTCCGAAAACTTGAACCCGAAATTATCGAAGCACTGAAACAACGTGCTGCCCGCAACGGCAGAAG
TGCTGAAATGGAACACCGTGCCATTTTGCGGGAAGTGTTATTGGTACTGAAAAAACGTAGCTTGGCCGAAGTACTGGCTA
CGATGCCCAACGTCGGAACAGATGCGGATTTTGAACGCATCCAAGGTAAGCAACAGGTTTCCGATGTATTTGCTTGA