Detailed information of TA system TA164122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 66160..66662
• Replicon: chromosome
• Accession: NZ_CP056751
• Organism: Enterobacter hormaechei strain RHBSTW-00216

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HV128_RS00365
• Protein ID: WP_047050704.1
• Coordinates: 66160..66414 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HV128_RS00370
• Protein ID: WP_047050702.1
• Coordinates: 66411..66662 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV128_RS00335	61624..62148	-	525	WP_047050709.1	lipocalin family protein	-
HV128_RS00340	62266..62991	+	726	WP_017383646.1	MerR family transcriptional regulator	-
HV128_RS00345	63091..63501	+	411	WP_022650126.1	hydroxyisourate hydrolase	-
HV128_RS00350	63604..64563	+	960	WP_047050707.1	DUF523 and DUF1722 domain-containing protein	-
HV128_RS00355	64710..65798	+	1089	WP_047050706.1	AAA family ATPase	-
HV128_RS00360	65929..66084	-	156	WP_154815872.1	hypothetical protein	-
HV128_RS00365	66160..66414	-	255	WP_047050704.1	Txe/YoeB family addiction module toxin	Toxin
HV128_RS00370	66411..66662	-	252	WP_047050702.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
HV128_RS00375	66913..68163	-	1251	WP_047050701.1	HlyD family efflux transporter periplasmic adaptor subunit	-
HV128_RS00380	68170..68919	-	750	WP_047050700.1	hypothetical protein	-
HV128_RS00385	68916..71012	-	2097	WP_047050699.1	peptidase domain-containing ABC transporter	-
HV128_RS00390	71080..71265	-	186	WP_063159820.1	hypothetical protein	-
HV128_RS00395	71289..71483	-	195	WP_000644465.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	45104..66662	21558

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10117.66 Da
• Isoelectric Point: 7.8747

>T164122 WP_047050704.1 NZ_CP056751:c66414-66160 [Enterobacter hormaechei]
VKITWSEEAWEDYLYWQETDKRMVRKINELIKISCRTPFEGIGKPEPLKHNLAGFWSRRITSEHRMVYAITEEAILIAAC
RYHY

Nucleotide

• Length: 255 bp

>T164122 NZ_CP072793:2026670-2027020 [Thiothrix unzii]
ATGCCTCAACTGCCCAGTTTTGTGGAGTTACCATCTTTTGAGCGATTTCGTGAGGATTATCTGAACGACGATGAGTACAG
GGATTTTCAACGTTTATTAATCGAAAGTCCCAAAGCAGGCGATGTCATTGCGAGTACAGGTGGTTTGCGGAAAATTCGTT
TTGAAGACAAGCGGCGGGGAAAAGGTAAGCGTGGTGGTTTGAGGGTTATTTACTACTACCAAACCAATGCTTTGGAATTC
TTGTTGTTCGCTATTTATGATAAGGATGAGGCAAGCGACTTGACCAGCAAGCAAAAAGTGGCGTTTAAGGCATTCCTTGA
ATCCGAATTGAAGTTGCGCTATCCACAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9343.57 Da
• Isoelectric Point: 4.7854

>AT164122 WP_047050702.1 NZ_CP056751:c66662-66411 [Enterobacter hormaechei]
MRVISYSEARQNLSATMVQTTEDRAPVLITRQNGESCVLMSLEEYNSLEETAYLMRSPANAKRLMNSIESLKSGSGKERD
IIE

Nucleotide

• Length: 252 bp

>AT164122 NZ_CP072793:2027047-2027361 [Thiothrix unzii]
ATGAAAAAACGTAATTTATTTGACGAATTGATGGAAGGTGTTGAAGCACTCAAAGCAGAGCGTGAGGGCAAAATCACCTT
GAAACGAGTGCAATTAGAGGTACTCGAATCGCCTGCAATTCAGCCCAGTGAAATATTGAAATTACGTGAATCTCGCCACT
TGTCGCGCTCTGTATTCGCTAATGCGATACGTACAAACCCGCGCACCGTAGAAAGTTGGGAGCAAGGGCGTAGTAAACCT
AATCCTCATGCGGTTCTATTAATGCGTTTGGTTGAAAAGTATCCAGAAACGCTGGAGCATTTGCGAGCTATTTGA