Detailed information of TA system TA164107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2095596..2096256
• Replicon: chromosome
• Accession: NZ_CP056747
• Organism: Enterobacter hormaechei strain RHBSTW-00217

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HV129_RS09830
• Protein ID: WP_047053529.1
• Coordinates: 2095596..2095949 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A2J0Q4Z7
• Locus tag: HV129_RS09835
• Protein ID: WP_017383313.1
• Coordinates: 2095954..2096256 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV129_RS09810	2092029..2092952	+	924	WP_047053526.1	L,D-transpeptidase	-
HV129_RS09820	2093441..2094358	+	918	WP_003859531.1	nitrogen assimilation transcriptional regulator NAC	-
HV129_RS09825	2094455..2095405	+	951	WP_003859532.1	HTH-type transcriptional regulator Cbl	-
HV129_RS09830	2095596..2095949	+	354	WP_047053529.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV129_RS09835	2095954..2096256	+	303	WP_017383313.1	helix-turn-helix transcriptional regulator	Antitoxin
HV129_RS09845	2096545..2098734	-	2190	WP_181539604.1	TonB-dependent siderophore receptor	-
HV129_RS09850	2098761..2100086	-	1326	WP_047053533.1	SidA/IucD/PvdA family monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (18-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13522.40 Da
• Isoelectric Point: 10.1729

>T164107 WP_047053529.1 NZ_CP056747:2095596-2095949 [Enterobacter hormaechei]
VWAIKTTDRFDDWFTSLNDSERASVLAALLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFNPNRTGI
VLCAGNKIGNERRFYDEMLLVADREYTRWLNTLKERN

Nucleotide

• Length: 354 bp

>T164107 NZ_CP072790:3176294-3176737 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11028.85 Da
• Isoelectric Point: 6.4727

>AT164107 WP_017383313.1 NZ_CP056747:2095954-2096256 [Enterobacter hormaechei]
MGRTLEQLIADEKPEVVASAQAMATDILLNIHLAELREKVQKTQVDMARALGIKQPTVAVMEKAGRDIKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT164107 NZ_CP072790:3176050-3176307 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A2J0Q4Z7