Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 82914..83416 Replicon chromosome
Accession NZ_CP056747
Organism Enterobacter hormaechei strain RHBSTW-00217

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HV129_RS00415 Protein ID WP_047050704.1
Coordinates 83162..83416 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HV129_RS00410 Protein ID WP_047050702.1
Coordinates 82914..83165 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV129_RS00385 78093..78287 + 195 WP_000644465.1 hypothetical protein -
HV129_RS00390 78311..78496 + 186 WP_001196016.1 hypothetical protein -
HV129_RS00395 78564..80660 + 2097 WP_047050699.1 peptidase domain-containing ABC transporter -
HV129_RS00400 80657..81406 + 750 WP_047050700.1 hypothetical protein -
HV129_RS00405 81413..82663 + 1251 WP_047050701.1 HlyD family efflux transporter periplasmic adaptor subunit -
HV129_RS00410 82914..83165 + 252 WP_047050702.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HV129_RS00415 83162..83416 + 255 WP_047050704.1 Txe/YoeB family addiction module toxin Toxin
HV129_RS00420 83492..83647 + 156 WP_154815872.1 hypothetical protein -
HV129_RS00425 83778..84866 - 1089 WP_047050706.1 AAA family ATPase -
HV129_RS00430 85013..85972 - 960 WP_047050707.1 DUF523 and DUF1722 domain-containing protein -
HV129_RS00435 86075..86485 - 411 WP_022650126.1 hydroxyisourate hydrolase -
HV129_RS00440 86585..87310 - 726 WP_017383646.1 MerR family transcriptional regulator -
HV129_RS00445 87428..87952 + 525 WP_047050709.1 lipocalin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10117.66 Da        Isoelectric Point: 7.8747

>T164100 WP_047050704.1 NZ_CP056747:83162-83416 [Enterobacter hormaechei]
VKITWSEEAWEDYLYWQETDKRMVRKINELIKISCRTPFEGIGKPEPLKHNLAGFWSRRITSEHRMVYAITEEAILIAAC
RYHY

Download         Length: 255 bp

>T164100 NZ_CP072790:c2970947-2970624 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9343.57 Da        Isoelectric Point: 4.7854

>AT164100 WP_047050702.1 NZ_CP056747:82914-83165 [Enterobacter hormaechei]
MRVISYSEARQNLSATMVQTTEDRAPVLITRQNGESCVLMSLEEYNSLEETAYLMRSPANAKRLMNSIESLKSGSGKERD
IIE

Download         Length: 252 bp

>AT164100 NZ_CP072790:c2971272-2971027 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References