Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 66160..66662 Replicon chromosome
Accession NZ_CP056742
Organism Enterobacter hormaechei strain RHBSTW-00220

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HV132_RS00365 Protein ID WP_047050704.1
Coordinates 66160..66414 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HV132_RS00370 Protein ID WP_047050702.1
Coordinates 66411..66662 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV132_RS00335 61624..62148 - 525 WP_047050709.1 lipocalin family protein -
HV132_RS00340 62266..62991 + 726 WP_017383646.1 MerR family transcriptional regulator -
HV132_RS00345 63091..63501 + 411 WP_022650126.1 hydroxyisourate hydrolase -
HV132_RS00350 63604..64563 + 960 WP_047050707.1 DUF523 and DUF1722 domain-containing protein -
HV132_RS00355 64710..65798 + 1089 WP_047050706.1 AAA family ATPase -
HV132_RS00360 65929..66084 - 156 WP_154815872.1 hypothetical protein -
HV132_RS00365 66160..66414 - 255 WP_047050704.1 Txe/YoeB family addiction module toxin Toxin
HV132_RS00370 66411..66662 - 252 WP_047050702.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HV132_RS00375 66913..68163 - 1251 WP_047050701.1 HlyD family efflux transporter periplasmic adaptor subunit -
HV132_RS00380 68170..68919 - 750 WP_047050700.1 hypothetical protein -
HV132_RS00385 68916..71012 - 2097 WP_047050699.1 peptidase domain-containing ABC transporter -
HV132_RS00390 71080..71265 - 186 WP_063159820.1 hypothetical protein -
HV132_RS00395 71289..71483 - 195 WP_000644465.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 45104..66662 21558


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10117.66 Da        Isoelectric Point: 7.8747

>T164078 WP_047050704.1 NZ_CP056742:c66414-66160 [Enterobacter hormaechei]
VKITWSEEAWEDYLYWQETDKRMVRKINELIKISCRTPFEGIGKPEPLKHNLAGFWSRRITSEHRMVYAITEEAILIAAC
RYHY

Download         Length: 255 bp

>T164078 NZ_CP072790:1546198-1547019 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACTTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9343.57 Da        Isoelectric Point: 4.7854

>AT164078 WP_047050702.1 NZ_CP056742:c66662-66411 [Enterobacter hormaechei]
MRVISYSEARQNLSATMVQTTEDRAPVLITRQNGESCVLMSLEEYNSLEETAYLMRSPANAKRLMNSIESLKSGSGKERD
IIE

Download         Length: 252 bp

>AT164078 NZ_CP072790:1547012-1547248 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References