Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 66160..66662 | Replicon | chromosome |
Accession | NZ_CP056742 | ||
Organism | Enterobacter hormaechei strain RHBSTW-00220 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | - |
Locus tag | HV132_RS00365 | Protein ID | WP_047050704.1 |
Coordinates | 66160..66414 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | - |
Locus tag | HV132_RS00370 | Protein ID | WP_047050702.1 |
Coordinates | 66411..66662 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV132_RS00335 | 61624..62148 | - | 525 | WP_047050709.1 | lipocalin family protein | - |
HV132_RS00340 | 62266..62991 | + | 726 | WP_017383646.1 | MerR family transcriptional regulator | - |
HV132_RS00345 | 63091..63501 | + | 411 | WP_022650126.1 | hydroxyisourate hydrolase | - |
HV132_RS00350 | 63604..64563 | + | 960 | WP_047050707.1 | DUF523 and DUF1722 domain-containing protein | - |
HV132_RS00355 | 64710..65798 | + | 1089 | WP_047050706.1 | AAA family ATPase | - |
HV132_RS00360 | 65929..66084 | - | 156 | WP_154815872.1 | hypothetical protein | - |
HV132_RS00365 | 66160..66414 | - | 255 | WP_047050704.1 | Txe/YoeB family addiction module toxin | Toxin |
HV132_RS00370 | 66411..66662 | - | 252 | WP_047050702.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
HV132_RS00375 | 66913..68163 | - | 1251 | WP_047050701.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
HV132_RS00380 | 68170..68919 | - | 750 | WP_047050700.1 | hypothetical protein | - |
HV132_RS00385 | 68916..71012 | - | 2097 | WP_047050699.1 | peptidase domain-containing ABC transporter | - |
HV132_RS00390 | 71080..71265 | - | 186 | WP_063159820.1 | hypothetical protein | - |
HV132_RS00395 | 71289..71483 | - | 195 | WP_000644465.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 45104..66662 | 21558 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10117.66 Da Isoelectric Point: 7.8747
>T164078 WP_047050704.1 NZ_CP056742:c66414-66160 [Enterobacter hormaechei]
VKITWSEEAWEDYLYWQETDKRMVRKINELIKISCRTPFEGIGKPEPLKHNLAGFWSRRITSEHRMVYAITEEAILIAAC
RYHY
VKITWSEEAWEDYLYWQETDKRMVRKINELIKISCRTPFEGIGKPEPLKHNLAGFWSRRITSEHRMVYAITEEAILIAAC
RYHY
Download Length: 255 bp
>T164078 NZ_CP072790:1546198-1547019 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACTTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACTTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9343.57 Da Isoelectric Point: 4.7854
>AT164078 WP_047050702.1 NZ_CP056742:c66662-66411 [Enterobacter hormaechei]
MRVISYSEARQNLSATMVQTTEDRAPVLITRQNGESCVLMSLEEYNSLEETAYLMRSPANAKRLMNSIESLKSGSGKERD
IIE
MRVISYSEARQNLSATMVQTTEDRAPVLITRQNGESCVLMSLEEYNSLEETAYLMRSPANAKRLMNSIESLKSGSGKERD
IIE
Download Length: 252 bp
>AT164078 NZ_CP072790:1547012-1547248 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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