Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 51648..52294 | Replicon | chromosome |
Accession | NZ_CP056742 | ||
Organism | Enterobacter hormaechei strain RHBSTW-00220 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | HV132_RS00280 | Protein ID | WP_181522317.1 |
Coordinates | 51648..51998 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A7H8UAV4 |
Locus tag | HV132_RS00285 | Protein ID | WP_045335986.1 |
Coordinates | 51995..52294 (+) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV132_RS00245 | 47325..47795 | + | 471 | WP_015703840.1 | DNA repair protein RadC | - |
HV132_RS00250 | 47808..48134 | + | 327 | WP_059443453.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
HV132_RS00255 | 48155..48475 | + | 321 | WP_059443702.1 | TA system toxin CbtA family protein | - |
HV132_RS00260 | 48770..50326 | + | 1557 | WP_047050722.1 | hypothetical protein | - |
HV132_RS00265 | 50366..50542 | - | 177 | WP_071962261.1 | toxin-antitoxin system HicB family antitoxin | - |
HV132_RS00270 | 50679..51020 | + | 342 | WP_006812446.1 | SymE family type I addiction module toxin | - |
HV132_RS00275 | 51123..51375 | + | 253 | Protein_54 | DNA-binding protein | - |
HV132_RS00280 | 51648..51998 | + | 351 | WP_181522317.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HV132_RS00285 | 51995..52294 | + | 300 | WP_045335986.1 | XRE family transcriptional regulator | Antitoxin |
HV132_RS00290 | 52359..53240 | - | 882 | WP_047050719.1 | helix-turn-helix domain-containing protein | - |
HV132_RS00295 | 53483..53962 | - | 480 | WP_047050718.1 | hypothetical protein | - |
HV132_RS00300 | 53964..54752 | - | 789 | WP_045329485.1 | winged helix-turn-helix domain-containing protein | - |
HV132_RS00305 | 55587..56189 | + | 603 | WP_047050717.1 | response regulator transcription factor | - |
HV132_RS00310 | 56242..56826 | + | 585 | WP_023299002.1 | type 1 fimbrial protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 45104..66662 | 21558 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13482.62 Da Isoelectric Point: 8.8416
>T164077 WP_181522317.1 NZ_CP056742:51648-51998 [Enterobacter hormaechei]
MWTVLFSKVFEQWLLEQEDGLQEKVLADLLNLQNYGPRLPRPYADTVKGSLYKNMKELRIQYAGRPVRAFFAFDPVRQAI
VLCAGDKRNDKTFYEKLIRIADAEFTLHLTSLEAAK
MWTVLFSKVFEQWLLEQEDGLQEKVLADLLNLQNYGPRLPRPYADTVKGSLYKNMKELRIQYAGRPVRAFFAFDPVRQAI
VLCAGDKRNDKTFYEKLIRIADAEFTLHLTSLEAAK
Download Length: 351 bp
>T164077 NZ_CP072790:c1395111-1394818 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 11129.87 Da Isoelectric Point: 6.4714
>AT164077 WP_045335986.1 NZ_CP056742:51995-52294 [Enterobacter hormaechei]
VKTLNEVIASRSPESQQRIQEMAEEMFLETGLQLLREELQLSQKHVADLMGVSQPAVTQLEQRGNDLKIATLKRYIEAMG
GKLSINVELPTGKRVAFHL
VKTLNEVIASRSPESQQRIQEMAEEMFLETGLQLLREELQLSQKHVADLMGVSQPAVTQLEQRGNDLKIATLKRYIEAMG
GKLSINVELPTGKRVAFHL
Download Length: 300 bp
>AT164077 NZ_CP072790:c1395377-1395108 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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