Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 51648..52294 Replicon chromosome
Accession NZ_CP056742
Organism Enterobacter hormaechei strain RHBSTW-00220

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV132_RS00280 Protein ID WP_181522317.1
Coordinates 51648..51998 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A7H8UAV4
Locus tag HV132_RS00285 Protein ID WP_045335986.1
Coordinates 51995..52294 (+) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV132_RS00245 47325..47795 + 471 WP_015703840.1 DNA repair protein RadC -
HV132_RS00250 47808..48134 + 327 WP_059443453.1 type IV toxin-antitoxin system YeeU family antitoxin -
HV132_RS00255 48155..48475 + 321 WP_059443702.1 TA system toxin CbtA family protein -
HV132_RS00260 48770..50326 + 1557 WP_047050722.1 hypothetical protein -
HV132_RS00265 50366..50542 - 177 WP_071962261.1 toxin-antitoxin system HicB family antitoxin -
HV132_RS00270 50679..51020 + 342 WP_006812446.1 SymE family type I addiction module toxin -
HV132_RS00275 51123..51375 + 253 Protein_54 DNA-binding protein -
HV132_RS00280 51648..51998 + 351 WP_181522317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV132_RS00285 51995..52294 + 300 WP_045335986.1 XRE family transcriptional regulator Antitoxin
HV132_RS00290 52359..53240 - 882 WP_047050719.1 helix-turn-helix domain-containing protein -
HV132_RS00295 53483..53962 - 480 WP_047050718.1 hypothetical protein -
HV132_RS00300 53964..54752 - 789 WP_045329485.1 winged helix-turn-helix domain-containing protein -
HV132_RS00305 55587..56189 + 603 WP_047050717.1 response regulator transcription factor -
HV132_RS00310 56242..56826 + 585 WP_023299002.1 type 1 fimbrial protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 45104..66662 21558


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-105)

Antitoxin

(12-88)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 13482.62 Da        Isoelectric Point: 8.8416

>T164077 WP_181522317.1 NZ_CP056742:51648-51998 [Enterobacter hormaechei]
MWTVLFSKVFEQWLLEQEDGLQEKVLADLLNLQNYGPRLPRPYADTVKGSLYKNMKELRIQYAGRPVRAFFAFDPVRQAI
VLCAGDKRNDKTFYEKLIRIADAEFTLHLTSLEAAK

Download         Length: 351 bp

>T164077 NZ_CP072790:c1395111-1394818 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11129.87 Da        Isoelectric Point: 6.4714

>AT164077 WP_045335986.1 NZ_CP056742:51995-52294 [Enterobacter hormaechei]
VKTLNEVIASRSPESQQRIQEMAEEMFLETGLQLLREELQLSQKHVADLMGVSQPAVTQLEQRGNDLKIATLKRYIEAMG
GKLSINVELPTGKRVAFHL

Download         Length: 300 bp

>AT164077 NZ_CP072790:c1395377-1395108 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7H8UAV4

References