Detailed information of TA system TA163955

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 82911..83413
• Replicon: chromosome
• Accession: NZ_CP056707
• Organism: Enterobacter hormaechei strain RHBSTW-00564

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HV236_RS00415
• Protein ID: WP_047050704.1
• Coordinates: 83159..83413 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HV236_RS00410
• Protein ID: WP_047050702.1
• Coordinates: 82911..83162 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV236_RS00385	78090..78284	+	195	WP_000644465.1	hypothetical protein	-
HV236_RS00390	78308..78493	+	186	WP_001196016.1	hypothetical protein	-
HV236_RS00395	78561..80657	+	2097	WP_047050699.1	peptidase domain-containing ABC transporter	-
HV236_RS00400	80654..81403	+	750	WP_047050700.1	hypothetical protein	-
HV236_RS00405	81410..82660	+	1251	WP_047050701.1	HlyD family efflux transporter periplasmic adaptor subunit	-
HV236_RS00410	82911..83162	+	252	WP_047050702.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
HV236_RS00415	83159..83413	+	255	WP_047050704.1	Txe/YoeB family addiction module toxin	Toxin
HV236_RS00420	83489..83644	+	156	WP_154815872.1	hypothetical protein	-
HV236_RS00425	83775..84863	-	1089	WP_047050706.1	AAA family ATPase	-
HV236_RS00430	85010..85969	-	960	WP_047050707.1	DUF523 and DUF1722 domain-containing protein	-
HV236_RS00435	86072..86482	-	411	WP_022650126.1	hydroxyisourate hydrolase	-
HV236_RS00440	86582..87307	-	726	WP_017383646.1	MerR family transcriptional regulator	-
HV236_RS00445	87425..87949	+	525	WP_047050709.1	lipocalin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10117.66 Da
• Isoelectric Point: 7.8747

>T163955 WP_047050704.1 NZ_CP056707:83159-83413 [Enterobacter hormaechei]
VKITWSEEAWEDYLYWQETDKRMVRKINELIKISCRTPFEGIGKPEPLKHNLAGFWSRRITSEHRMVYAITEEAILIAAC
RYHY

Nucleotide

• Length: 255 bp

>T163955 NZ_CP072766:2337022-2337759 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATCCAGCAGTATTCGGTACGATGG
AATGGCATATGGAAGAAGACTATACAAAAAGTTTAAACGCATTTTTAGATTCATACGGGGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAAGCGGCAAAAGAATTAAATACTAACTTTCGCGGTATCCGTTCTCAATTTAGTACGATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9343.57 Da
• Isoelectric Point: 4.7854

>AT163955 WP_047050702.1 NZ_CP056707:82911-83162 [Enterobacter hormaechei]
MRVISYSEARQNLSATMVQTTEDRAPVLITRQNGESCVLMSLEEYNSLEETAYLMRSPANAKRLMNSIESLKSGSGKERD
IIE

Nucleotide

• Length: 252 bp

>AT163955 NZ_CP072766:2337872-2337997 [Bacillus cereus]
GTGATAAAAGATAATAACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCATTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA