Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2017833..2018493 Replicon chromosome
Accession NZ_CP056701
Organism Klebsiella grimontii strain RHBSTW-00577

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV240_RS09690 Protein ID WP_049085818.1
Coordinates 2017833..2018186 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1DQ94
Locus tag HV240_RS09695 Protein ID WP_004132739.1
Coordinates 2018191..2018493 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV240_RS09665 2013217..2013984 - 768 WP_004132727.1 molybdopterin-dependent oxidoreductase -
HV240_RS09670 2013974..2014582 - 609 WP_004132729.1 cytochrome b/b6 domain-containing protein -
HV240_RS09675 2014597..2015223 - 627 WP_004132731.1 hypothetical protein -
HV240_RS09680 2015363..2016031 + 669 WP_004132733.1 heavy metal response regulator transcription factor -
HV240_RS09685 2016031..2017449 + 1419 WP_064411585.1 heavy metal sensor histidine kinase -
HV240_RS09690 2017833..2018186 + 354 WP_049085818.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV240_RS09695 2018191..2018493 + 303 WP_004132739.1 XRE family transcriptional regulator Antitoxin
HV240_RS09700 2018584..2018754 + 171 WP_177929058.1 helix-turn-helix domain-containing protein -
HV240_RS09705 2018877..2019080 + 204 Protein_1903 hypothetical protein -
HV240_RS09710 2019081..2019413 + 333 WP_024359977.1 type II toxin-antitoxin system PemK/MazF family toxin -
HV240_RS09720 2019737..2021194 + 1458 WP_004136541.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
HV240_RS09730 2021580..2022854 + 1275 WP_047730338.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13666.67 Da        Isoelectric Point: 10.1718

>T163938 WP_049085818.1 NZ_CP056701:2017833-2018186 [Klebsiella grimontii]
VWMIKTTDTFERWFTSLNDTDRARVLAALLVLREKGPGLSRPYADTLRGSRYSNMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKERE

Download         Length: 354 bp

>T163938 NZ_CP072765:2873857-2874234 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11072.83 Da        Isoelectric Point: 5.7424

>AT163938 WP_004132739.1 NZ_CP056701:2018191-2018493 [Klebsiella grimontii]
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL

Download         Length: 303 bp

>AT163938 NZ_CP072765:2873603-2873860 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References