Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 12945..13806 Replicon plasmid pRHBSTW-00605_2
Accession NZ_CP056698
Organism Escherichia marmotae strain RHBSTW-00605

Toxin (Protein)


Gene name yhaV Uniprot ID A0A7W3G1F8
Locus tag HV246_RS23375 Protein ID WP_024195926.1
Coordinates 12945..13439 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A7W3G1H0
Locus tag HV246_RS23380 Protein ID WP_001559862.1
Coordinates 13462..13806 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV246_RS23365 8184..8402 - 219 WP_000813629.1 type II toxin-antitoxin system antitoxin CcdA -
HV246_RS23370 8957..12763 - 3807 WP_001559860.1 hypothetical protein -
HV246_RS23375 12945..13439 - 495 WP_024195926.1 type II toxin-antitoxin system YhaV family toxin Toxin
HV246_RS23380 13462..13806 - 345 WP_001559862.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
HV246_RS23385 14050..14127 - 78 Protein_13 helix-turn-helix domain-containing protein -
HV246_RS23390 14498..15535 + 1038 WP_181479327.1 nucleotidyltransferase -
HV246_RS23395 16232..16654 + 423 WP_181479328.1 universal stress protein -
HV246_RS23400 16851..17360 - 510 WP_077768941.1 uracil-DNA glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..127911 127911


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(11-147)

Antitoxin

PrlF antitoxin

(16-114)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 19275.36 Da        Isoelectric Point: 8.7864

>T163925 WP_024195926.1 NZ_CP056698:c13439-12945 [Escherichia marmotae]
MEYLEINGWKICFHECFLRQITGLMKKVAELKASKPLEYHKKKETKLLVAIERVIEERITANPLDPQFRQGNTLGEEYKH
WFRAKFLMQFRLFYRCSQEHKTIVIGWVNGFDTLRAYDSRTDAYKVFGEMLKAGNPPDDWDTLLCEAGKATATTNMVDFL
TKRI

Download         Length: 495 bp

>T163925 NZ_CP072765:c2197903-2197574 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12755.59 Da        Isoelectric Point: 4.6652

>AT163925 WP_001559862.1 NZ_CP056698:c13806-13462 [Escherichia marmotae]
MATQILNSAEVSLRAESRLTERSQTTIPAVIRDALHLKPGEYIHYTLLAGGKVIMSRQNEEQDDPVISQFLTFLENDMKK
NPQKIAPVPTMFWESMKALTAGINVDLDAPLTED

Download         Length: 345 bp

>AT163925 NZ_CP072765:c2198277-2197900 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3G1F8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W3G1H0

References