Detailed information of TA system TA163920

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-OrzO/Ldr(toxin)
• Location: 2508890..2509113
• Replicon: chromosome
• Accession: NZ_CP056697
• Organism: Escherichia marmotae strain RHBSTW-00605

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A7H9K3A2
• Locus tag: HV246_RS12000
• Protein ID: WP_032141347.1
• Coordinates: 2509006..2509113 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	OrzO
Locus tag	-
Coordinates	2508890..2508956 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV246_RS11975	2504169..2505563	-	1395	WP_000087125.1	YchO/YchP family invasin	-
HV246_RS11980	2505747..2506100	+	354	WP_001169672.1	DsrE/F sulfur relay family protein YchN	-
HV246_RS11985	2506144..2506839	-	696	WP_001516523.1	glutathione-specific gamma-glutamylcyclotransferase	-
HV246_RS11990	2506997..2507227	-	231	WP_001146437.1	putative cation transport regulator ChaB	-
HV246_RS11995	2507496..2508596	+	1101	WP_001516524.1	sodium-potassium/proton antiporter ChaA	-
-	2508890..2508956	-	67	-	-	Antitoxin
HV246_RS12000	2509006..2509113	+	108	WP_032141347.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
HV246_RS12005	2509293..2510147	-	855	WP_000811071.1	3-deoxy-8-phosphooctulonate synthase	-
HV246_RS12010	2510183..2510992	-	810	WP_001257034.1	invasion regulator SirB1	-
HV246_RS12015	2510996..2511388	-	393	WP_000200357.1	invasion regulator SirB2	-
HV246_RS12020	2511385..2512218	-	834	WP_105276063.1	peptide chain release factor N(5)-glutamine methyltransferase	-
HV246_RS12025	2512218..2513300	-	1083	WP_000804714.1	peptide chain release factor 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3953.71 Da
• Isoelectric Point: 11.4779

>T163920 WP_032141347.1 NZ_CP056697:2509006-2509113 [Escherichia marmotae]
MTLAQFAITFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T163920 NZ_CP072765:c1575877-1575476 [Mycobacterium tuberculosis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin

Nucleotide

• Length: 67 bp

>AT163920 NZ_CP056697:c2508956-2508890 [Escherichia marmotae]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A7H9K3A2

Antitoxin