Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2197014..2197576 Replicon chromosome
Accession NZ_CP056697
Organism Escherichia marmotae strain RHBSTW-00605

Toxin (Protein)


Gene name higB Uniprot ID A0A7H9K4H3
Locus tag HV246_RS10345 Protein ID WP_001516386.1
Coordinates 2197014..2197292 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HV246_RS10350 Protein ID WP_000781370.1
Coordinates 2197292..2197576 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV246_RS10315 2192524..2192853 - 330 Protein_2012 omptin family outer membrane protease -
HV246_RS10320 2192853..2193065 - 213 Protein_2013 peroxiredoxin OsmC -
HV246_RS10325 2193388..2193603 + 216 WP_000495761.1 biofilm-dependent modulation protein -
HV246_RS10330 2193694..2193831 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HV246_RS10335 2193987..2195684 + 1698 WP_001516384.1 malate dehydrogenase -
HV246_RS10340 2195818..2196828 + 1011 WP_000642389.1 alcohol dehydrogenase AdhP -
HV246_RS10345 2197014..2197292 + 279 WP_001516386.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV246_RS10350 2197292..2197576 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HV246_RS10355 2197804..2198457 - 654 WP_000045637.1 formate dehydrogenase-N subunit gamma -
HV246_RS10360 2198450..2199334 - 885 WP_001240589.1 formate dehydrogenase N subunit beta -
HV246_RS10365 2199347..2202394 - 3048 WP_077633351.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10623.19 Da        Isoelectric Point: 6.8682

>T163918 WP_001516386.1 NZ_CP056697:2197014-2197292 [Escherichia marmotae]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDEIWTISVSGNWRLTFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T163918 NZ_CP072765:c1388984-1388691 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT163918 WP_000781370.1 NZ_CP056697:2197292-2197576 [Escherichia marmotae]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT163918 NZ_CP072765:c1389250-1388981 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H9K4H3

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References