Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1226964..1227691 Replicon chromosome
Accession NZ_CP056691
Organism Enterobacter hormaechei strain RHBSTW-00626

Toxin (Protein)


Gene name higB Uniprot ID A0A9E6WR45
Locus tag HV249_RS05900 Protein ID WP_045623285.1
Coordinates 1227380..1227691 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV249_RS05895 Protein ID WP_045623284.1
Coordinates 1226964..1227383 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV249_RS05860 1222561..1222788 + 228 WP_124304273.1 hypothetical protein -
HV249_RS05865 1223590..1223784 + 195 Protein_1137 hypothetical protein -
HV249_RS05870 1223797..1224648 + 852 Protein_1138 RHS domain-containing protein -
HV249_RS05875 1224645..1225127 + 483 WP_063139119.1 immunity 26/phosphotriesterase HocA family protein -
HV249_RS05880 1225341..1225640 + 300 WP_124304274.1 hypothetical protein -
HV249_RS05885 1225644..1225886 - 243 WP_124304275.1 hypothetical protein -
HV249_RS05890 1226250..1226696 + 447 WP_045623318.1 hypothetical protein -
HV249_RS05895 1226964..1227383 - 420 WP_045623284.1 helix-turn-helix domain-containing protein Antitoxin
HV249_RS05900 1227380..1227691 - 312 WP_045623285.1 type II toxin-antitoxin system HigB family toxin Toxin
HV249_RS05905 1227912..1228322 - 411 WP_023299534.1 ASCH domain-containing protein -
HV249_RS05910 1228523..1228978 - 456 WP_023305643.1 hypothetical protein -
HV249_RS05915 1229682..1229894 + 213 WP_022647355.1 RNA chaperone/antiterminator CspA -
HV249_RS05920 1230121..1231017 - 897 WP_045623287.1 LysR family transcriptional regulator -
HV249_RS05925 1231123..1231902 + 780 WP_088581799.1 acetolactate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12453.32 Da        Isoelectric Point: 9.8331

>T163892 WP_045623285.1 NZ_CP056691:c1227691-1227380 [Enterobacter hormaechei]
MPAVSRAPFDAATRHFPIQELALEDLYWVLKGEHYPSPDDMRKRFPSRERMKYREKWWVIDVGGGYLRVMLFTDFERGKL
FIKHTSTHADYDKLTDLYRRKKE

Download         Length: 312 bp

>T163892 NZ_CP072764:3776087-3776344 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15522.56 Da        Isoelectric Point: 4.7722

>AT163892 WP_045623284.1 NZ_CP056691:c1227383-1226964 [Enterobacter hormaechei]
MNFSAAIKAANDLTRELPFLGSSPSRQDYEDAMGLVEYLIEHDPDSPLVEMLTAKIDKYENESPEFAEFNARVASIPSGV
ALLRTLMDQYHLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGVQVSAFVGN

Download         Length: 420 bp

>AT163892 NZ_CP072764:3775815-3776090 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References