Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 44961..45611 Replicon chromosome
Accession NZ_CP056682
Organism Klebsiella grimontii strain RHBSTW-00634

Toxin (Protein)


Gene name higB Uniprot ID A0A9E1GCI7
Locus tag HV252_RS00220 Protein ID WP_024360564.1
Coordinates 44961..45302 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1GGB7
Locus tag HV252_RS00225 Protein ID WP_024360565.1
Coordinates 45312..45611 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV252_RS00205 41194..42513 + 1320 WP_004133107.1 MFS transporter -
HV252_RS00210 42659..44050 + 1392 WP_004126843.1 hexose-6-phosphate:phosphate antiporter -
HV252_RS00215 44262..44714 + 453 WP_181511624.1 DUF1198 domain-containing protein -
HV252_RS00220 44961..45302 + 342 WP_024360564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV252_RS00225 45312..45611 + 300 WP_024360565.1 helix-turn-helix transcriptional regulator Antitoxin
HV252_RS00230 45729..46910 + 1182 WP_024360566.1 purine ribonucleoside efflux pump NepI -
HV252_RS00235 47029..48408 - 1380 WP_004133118.1 carbohydrate porin -
HV252_RS00240 48511..48813 - 303 WP_004855598.1 PTS lactose/cellobiose transporter subunit IIA -
HV252_RS00245 48921..50246 - 1326 WP_004133122.1 PTS sugar transporter subunit IIC -
HV252_RS00250 50258..50569 - 312 WP_004133123.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-83)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13091.97 Da        Isoelectric Point: 5.7558

>T163867 WP_024360564.1 NZ_CP056682:44961-45302 [Klebsiella grimontii]
MWDVETTEVFDKWFEAQIEALKEDMLAAMVILSEYGPQLGRPFADTVNDSAFSNMKELRVQHRGSPIRAFFVFDPSRRGI
VLCAGDKTGLNEKRFYKDMIKLADAEYRKHLNQ

Download         Length: 342 bp

>T163867 NZ_CP072764:2204648-2205025 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10994.92 Da        Isoelectric Point: 9.7256

>AT163867 WP_024360565.1 NZ_CP056682:45312-45611 [Klebsiella grimontii]
MATLKELMAKQSPESQARIAEKVEEMRQAIALSMLREELNMSQAELAKAMGVKQPTIAKMEQADNDPRLSTLKRYVVALG
GELSIDVKLPTGKRIAFHL

Download         Length: 300 bp

>AT163867 NZ_CP072764:2205067-2205516 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References