Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3664893..3665620 Replicon chromosome
Accession NZ_CP056676
Organism Enterobacter hormaechei strain RHBSTW-00642

Toxin (Protein)


Gene name higB Uniprot ID A0A9E6WR45
Locus tag HV254_RS17795 Protein ID WP_045623285.1
Coordinates 3664893..3665204 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV254_RS17800 Protein ID WP_045623284.1
Coordinates 3665201..3665620 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV254_RS17770 3660682..3661461 - 780 WP_088581799.1 acetolactate decarboxylase -
HV254_RS17775 3661567..3662463 + 897 WP_045623287.1 LysR family transcriptional regulator -
HV254_RS17780 3662690..3662902 - 213 WP_022647355.1 RNA chaperone/antiterminator CspA -
HV254_RS17785 3663606..3664061 + 456 WP_023305643.1 hypothetical protein -
HV254_RS17790 3664262..3664672 + 411 WP_023299534.1 ASCH domain-containing protein -
HV254_RS17795 3664893..3665204 + 312 WP_045623285.1 type II toxin-antitoxin system HigB family toxin Toxin
HV254_RS17800 3665201..3665620 + 420 WP_045623284.1 helix-turn-helix domain-containing protein Antitoxin
HV254_RS17805 3665888..3666334 - 447 WP_045623318.1 hypothetical protein -
HV254_RS17810 3666698..3666940 + 243 WP_124304275.1 hypothetical protein -
HV254_RS17815 3666944..3667243 - 300 WP_124304274.1 hypothetical protein -
HV254_RS17820 3667457..3667939 - 483 WP_063139119.1 immunity 26/phosphotriesterase HocA family protein -
HV254_RS17825 3667936..3668730 - 795 Protein_3486 RHS domain-containing protein -
HV254_RS17830 3668800..3668994 - 195 Protein_3487 hypothetical protein -
HV254_RS17835 3669796..3670023 - 228 WP_124304273.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12453.32 Da        Isoelectric Point: 9.8331

>T163860 WP_045623285.1 NZ_CP056676:3664893-3665204 [Enterobacter hormaechei]
MPAVSRAPFDAATRHFPIQELALEDLYWVLKGEHYPSPDDMRKRFPSRERMKYREKWWVIDVGGGYLRVMLFTDFERGKL
FIKHTSTHADYDKLTDLYRRKKE

Download         Length: 312 bp

>T163860 NZ_CP072764:1539754-1540575 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15522.56 Da        Isoelectric Point: 4.7722

>AT163860 WP_045623284.1 NZ_CP056676:3665201-3665620 [Enterobacter hormaechei]
MNFSAAIKAANDLTRELPFLGSSPSRQDYEDAMGLVEYLIEHDPDSPLVEMLTAKIDKYENESPEFAEFNARVASIPSGV
ALLRTLMDQYHLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGVQVSAFVGN

Download         Length: 420 bp

>AT163860 NZ_CP072764:1540568-1540804 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References