Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2311644..2312206 Replicon chromosome
Accession NZ_CP056597
Organism Citrobacter freundii strain RHBSTW-00334

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV164_RS10780 Protein ID WP_181540888.1
Coordinates 2311928..2312206 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV164_RS10775 Protein ID WP_096757032.1
Coordinates 2311644..2311928 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV164_RS10760 2306945..2309992 + 3048 WP_117342799.1 formate dehydrogenase-N subunit alpha -
HV164_RS10765 2310006..2310890 + 885 WP_115258486.1 formate dehydrogenase N subunit beta -
HV164_RS10770 2310883..2311539 + 657 WP_096757031.1 formate dehydrogenase-N subunit gamma -
HV164_RS10775 2311644..2311928 - 285 WP_096757032.1 HigA family addiction module antidote protein Antitoxin
HV164_RS10780 2311928..2312206 - 279 WP_181540888.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV164_RS10785 2312393..2314108 - 1716 WP_181625864.1 ATP-binding cassette domain-containing protein -
HV164_RS10790 2314419..2316116 - 1698 WP_115258488.1 malate dehydrogenase -
HV164_RS10795 2316296..2316436 - 141 WP_096757036.1 stationary-phase-induced ribosome-associated protein -
HV164_RS10800 2316665..2317096 + 432 WP_096757037.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10611.09 Da        Isoelectric Point: 9.5320

>T163772 WP_181540888.1 NZ_CP056597:c2312206-2311928 [Citrobacter freundii]
MIMNFRHKGLRDLFLQGRTSGVTAKHVRRLRHRLAVIDAASHVTDINMPGYKLHALTGDRDGVWSISVPGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T163772 NZ_CP072762:3571873-3572217 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10327.05 Da        Isoelectric Point: 8.8094

>AT163772 WP_096757032.1 NZ_CP056597:c2311928-2311644 [Citrobacter freundii]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNAWSLAEAQ
KSVDISRLRKLVAQ

Download         Length: 285 bp

>AT163772 NZ_CP072762:3572214-3572543 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References