Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 343721..344307 Replicon chromosome
Accession NZ_CP056530
Organism Klebsiella pneumoniae strain RHBSTW-00433

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag HV193_RS01620 Protein ID WP_002920800.1
Coordinates 343939..344307 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag HV193_RS01615 Protein ID WP_004174006.1
Coordinates 343721..343942 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV193_RS01595 339878..340804 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
HV193_RS01600 340801..342078 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
HV193_RS01605 342075..342842 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HV193_RS01610 342844..343557 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
HV193_RS01615 343721..343942 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HV193_RS01620 343939..344307 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HV193_RS01625 344579..345895 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
HV193_RS01630 346002..346889 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
HV193_RS01635 346886..347731 + 846 WP_060415936.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
HV193_RS01640 347733..348803 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 342075..349540 7465


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T163616 WP_002920800.1 NZ_CP056530:343939-344307 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T163616 NZ_CP072689:2211260-2212582 [Escherichia marmotae]
ATGCCAAAACTTGTCACGTGGATGAACAACCAGCGGGTAGGCGAGTTGACGAAGCTGACCAACGGTGCCCATACCTTTAA
GTATGCGCCGGAGTGGTTGGCCAACCGTTATGCCAGGCCATTGTCGCTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGCGACCGCATCGTTAAACGTTATCAT
GCTAAATCCAGGCAACCGTTTGATTTATTGTCAGAAATAGGGCGAGATAGCGTTGGCGCCGTGACGTTATTACCAGAAGA
CGAAACCGTGACGCGCCCAATAATGGTATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGGGAGGAAAATAACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACTGCGCTG
CTCAGAATGGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCATATCATTAAATTGCCGATTGGTGAAAT
CAGACAGCCCAATGCGACGCTCGATCTCAGTCAGAGTGTTGATAATGAGTATTACTGTCTGCTGCTGGCAAAAGAATTCG
GGTTGAATGTTCCCGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGCTTTGACAGGCGCTGG
AATACTGAACGAACGGTTTTACTTCGCTTGCCGCAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCTGACGGAGGCCCTGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTATTCCAGTGGTTGATTGGCTCGACAGACGGCCATGCGAAAAATTTCTCAGTGTTTATCCAG
GCCGGTGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCGGGAATACATAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAGAAAAACGGAAATCGATAAAATATATCCGCGACATT
TTTTGGCGACAGCAAAGGCACTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCC
GCAGCATTGGATAACGTGAAGGCTTCATTACCGGCAGATTTTCCGGAGAACGTGTTGACGGCAATTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCAGAGAATATGGAATTAAGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT163616 WP_004174006.1 NZ_CP056530:343721-343942 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT163616 NZ_CP072689:2210994-2211260 [Escherichia marmotae]
ATGATGAGCTTTCCGATGATCTATAGCCCAACGCAATTAGCAAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATAAAACAGGCGACTATTTCCAATTTCGAAAATAACCCTGACAACACCACAC
TAACGACATTTTTTAAGATATTACAGTCACTTAATCTCTCGATGACGCTATGCGACACGAAAAATGACTCGCCAGAATCA
ACCGATCAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References