Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1174654..1175381 Replicon chromosome
Accession NZ_CP056455
Organism Enterobacter hormaechei strain RHBSTW-00492

Toxin (Protein)


Gene name higB Uniprot ID A0A9E6WR45
Locus tag HV218_RS05530 Protein ID WP_045623285.1
Coordinates 1175070..1175381 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV218_RS05525 Protein ID WP_045623284.1
Coordinates 1174654..1175073 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV218_RS05490 1170251..1170478 + 228 WP_124304273.1 hypothetical protein -
HV218_RS05495 1171280..1171474 + 195 Protein_1063 hypothetical protein -
HV218_RS05500 1171487..1172338 + 852 Protein_1064 RHS domain-containing protein -
HV218_RS05505 1172335..1172817 + 483 WP_063139119.1 immunity 26/phosphotriesterase HocA family protein -
HV218_RS05510 1173031..1173330 + 300 WP_124304274.1 hypothetical protein -
HV218_RS05515 1173334..1173576 - 243 WP_124304275.1 hypothetical protein -
HV218_RS05520 1173940..1174386 + 447 WP_045623318.1 hypothetical protein -
HV218_RS05525 1174654..1175073 - 420 WP_045623284.1 helix-turn-helix domain-containing protein Antitoxin
HV218_RS05530 1175070..1175381 - 312 WP_045623285.1 type II toxin-antitoxin system HigB family toxin Toxin
HV218_RS05535 1175602..1176012 - 411 WP_023299534.1 ASCH domain-containing protein -
HV218_RS05540 1176213..1176668 - 456 WP_023305643.1 hypothetical protein -
HV218_RS05545 1177372..1177584 + 213 WP_022647355.1 RNA chaperone/antiterminator CspA -
HV218_RS05550 1177811..1178707 - 897 WP_045623287.1 LysR family transcriptional regulator -
HV218_RS05555 1178813..1179592 + 780 WP_088581799.1 acetolactate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12453.32 Da        Isoelectric Point: 9.8331

>T163521 WP_045623285.1 NZ_CP056455:c1175381-1175070 [Enterobacter hormaechei]
MPAVSRAPFDAATRHFPIQELALEDLYWVLKGEHYPSPDDMRKRFPSRERMKYREKWWVIDVGGGYLRVMLFTDFERGKL
FIKHTSTHADYDKLTDLYRRKKE

Download         Length: 312 bp

>T163521 NZ_CP072634:2290040-2290264 [Chloracidobacterium sp. D]
ATGACGAAACTGCCGCGCGTCAAAGGTCAAGAACTTATTGCGGCGCTGCACAAGGCTGGCTTTGACGTAGTGCGTATCAA
GGGAAGCCATCATTTTCTGCGCCATTCTGATGGCCGCTGTACCGTTATACCTGTTCATCGCGGAGAAACCATTGGACCAG
GTTTGATGTCCAAGATTCTGCGCGATTGTGAGATCACGTCTGAAGCGTTGCTGGAGCTTCTGTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15522.56 Da        Isoelectric Point: 4.7722

>AT163521 WP_045623284.1 NZ_CP056455:c1175073-1174654 [Enterobacter hormaechei]
MNFSAAIKAANDLTRELPFLGSSPSRQDYEDAMGLVEYLIEHDPDSPLVEMLTAKIDKYENESPEFAEFNARVASIPSGV
ALLRTLMDQYHLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGVQVSAFVGN

Download         Length: 420 bp

>AT163521 NZ_CP072634:2289828-2290043 [Chloracidobacterium sp. D]
ATGCAAAGAGAATTCAGCGTCATCATTGAGCGCGATCCGGAAGGTTACTATGTAGCCAGTGTTCCTGAATTACGCGGCTG
CCATACTCAAGCCAAATCCCTGGATACCCTGATGAAGCGAGTCCGCGAAGCCATCGAGCTGTGCCTGGAAGTCGAAGGGG
AACATACCTCACGTCAGGAATTCGTAGGGATTCAGCGCGTCTGGGTTGAAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References