Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 357529..358175 | Replicon | chromosome |
Accession | NZ_CP056432 | ||
Organism | Klebsiella pneumoniae strain RHBSTW-00510 |
Toxin (Protein)
Gene name | higB | Uniprot ID | W9BBY1 |
Locus tag | HV225_RS01655 | Protein ID | WP_016529833.1 |
Coordinates | 357529..357876 (+) | Length | 116 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | W8UB68 |
Locus tag | HV225_RS01660 | Protein ID | WP_002920557.1 |
Coordinates | 357876..358175 (+) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV225_RS01645 | 353455..354888 | + | 1434 | WP_002920564.1 | glycogen synthase GlgA | - |
HV225_RS01650 | 354906..357353 | + | 2448 | WP_002920561.1 | glycogen phosphorylase | - |
HV225_RS01655 | 357529..357876 | + | 348 | WP_016529833.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HV225_RS01660 | 357876..358175 | + | 300 | WP_002920557.1 | helix-turn-helix transcriptional regulator | Antitoxin |
HV225_RS01665 | 358238..359746 | - | 1509 | WP_023301456.1 | glycerol-3-phosphate dehydrogenase | - |
HV225_RS01670 | 359951..360280 | + | 330 | WP_002920552.1 | thiosulfate sulfurtransferase GlpE | - |
HV225_RS01675 | 360331..360774 | + | 444 | Protein_330 | rhomboid family intramembrane serine protease GlpG | - |
HV225_RS01680 | 360833..361876 | + | 1044 | WP_116280962.1 | IS481-like element ISKpn28 family transposase | - |
HV225_RS01685 | 361867..362262 | + | 396 | Protein_332 | rhomboid family intramembrane serine protease | - |
HV225_RS01690 | 362312..363070 | + | 759 | WP_032456686.1 | DeoR/GlpR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 361382..361876 | 494 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 13549.56 Da Isoelectric Point: 5.6749
>T163479 WP_016529833.1 NZ_CP056432:357529-357876 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER
Download Length: 348 bp
>T163479 NZ_CP072605:645992-646330 [Burkholderia latens]
ATGGTTGACATACTGAAATCCATGCCCTACAGTTCGCCTTCGTACAGTATCCGGACCACAGACGTCTTCGACGCGTGGTT
TGCCGCCCTTACGGATCGCGTCGCGCGGCGCCGCATCCAGGCGCGCATCGACCGTCTGTCGATGGGCAACCCGGGCGACT
GGAAATCCGCCGGCTCACCGATCGTCGAAATGCGTATCGACCACGGCCCCGGCTATCGCGTCTACAACGCGAGGCGCGAA
ACGATATGGGTGATCCTGCTCTGCGGCGGTGACAAGTCGACACAACAGGCGGACATCCGGGGCGCGCACGCGATGCTCGA
ACGGCTCGACCTGGAGTAA
ATGGTTGACATACTGAAATCCATGCCCTACAGTTCGCCTTCGTACAGTATCCGGACCACAGACGTCTTCGACGCGTGGTT
TGCCGCCCTTACGGATCGCGTCGCGCGGCGCCGCATCCAGGCGCGCATCGACCGTCTGTCGATGGGCAACCCGGGCGACT
GGAAATCCGCCGGCTCACCGATCGTCGAAATGCGTATCGACCACGGCCCCGGCTATCGCGTCTACAACGCGAGGCGCGAA
ACGATATGGGTGATCCTGCTCTGCGGCGGTGACAAGTCGACACAACAGGCGGACATCCGGGGCGCGCACGCGATGCTCGA
ACGGCTCGACCTGGAGTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 10800.58 Da Isoelectric Point: 10.1464
>AT163479 WP_002920557.1 NZ_CP056432:357876-358175 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL
Download Length: 300 bp
>AT163479 NZ_CP072605:646334-646633 [Burkholderia latens]
ATGGACAAGATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGACGACGACATGGCCGAGTATTTCGAGGC
CTGTCTGCAGGAAGCCGGCGACGACCCGGCCTTCATCGCGCATGCGCTTGGCGTGATCGCGCGCGCGCGCGGGATGTCGC
ATGTCGCGCGCGACGCCGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTGATCAAGGCGCTCGGCCTGCAGCTGCACGGCGCGAAGGCGCACGCGTGA
ATGGACAAGATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGACGACGACATGGCCGAGTATTTCGAGGC
CTGTCTGCAGGAAGCCGGCGACGACCCGGCCTTCATCGCGCATGCGCTTGGCGTGATCGCGCGCGCGCGCGGGATGTCGC
ATGTCGCGCGCGACGCCGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTGATCAAGGCGCTCGGCCTGCAGCTGCACGGCGCGAAGGCGCACGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | W9BBY1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E1CBF8 |