Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 331340..331926 Replicon chromosome
Accession NZ_CP056432
Organism Klebsiella pneumoniae strain RHBSTW-00510

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HV225_RS01545 Protein ID WP_023285605.1
Coordinates 331558..331926 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag HV225_RS01540 Protein ID WP_004174006.1
Coordinates 331340..331561 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV225_RS01520 327497..328423 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
HV225_RS01525 328420..329697 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
HV225_RS01530 329694..330461 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HV225_RS01535 330463..331176 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
HV225_RS01540 331340..331561 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HV225_RS01545 331558..331926 + 369 WP_023285605.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HV225_RS01550 332199..333515 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
HV225_RS01555 333622..334509 + 888 WP_032738214.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
HV225_RS01560 334506..335351 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
HV225_RS01565 335353..336423 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 328420..337160 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13534.89 Da        Isoelectric Point: 8.6410

>T163478 WP_023285605.1 NZ_CP056432:331558-331926 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGITVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T163478 NZ_CP072603:c39799-39389 [Burkholderia latens]
ATGACGCTGTACCTGCTCGATACAAACATTTTGTCGAACGTGATCCGCGACCCGCGCGGCGCATGCGCCACCCGGATCGG
AGAAACCCCGCCGGAGCAAGTGTGCACCTCGATCGTCGTTGCGGCGGAACTGCGGTTCGGCGTCTGGAAGCGTGGCTCGT
CGACGCTCGCGCAGCGCGTCGAGCAGCTGCTCGCGAGCCTGACCGTGTTGCCGCTGCAGCCCGACGCGGACCGCTGCTAC
GGGCGGTTGCGGGCCGAGCTCGAAAAGCAAGGCCAGTTGATCGGCGCCAACGACATGCTGATCGCCGCGCATGCGCTGGC
TGTCGACGCGGTCCTGGTCACGGACAACACGGCTGAATTTACCCGTGTCGCCGGGTTGCCGGTCGAAAACTGGCTGCGAT
CCGCGACGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT163478 WP_004174006.1 NZ_CP056432:331340-331561 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT163478 NZ_CP072603:c40038-39796 [Burkholderia latens]
ATGCCAACCCATGACACCCGCCACGCGCGCCTGTTTCGCAACGGGCGAAGCCAAGCCGTGCGGATTCCGCGCGAATTCGA
ATTGCCGGTCTCGGAGGTCACCATCCACCGGGAAGGCCGGCGCCTGATCATCGAGCCCGTAGAGGCCGCGCCCTTGCGCG
AGCTGTTCGCCCAATGGACCCCGCTGGACGAGACCTTTCCGGACATCGTGGATCTTCCGCCTGAACCGGTCGACATCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References