Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3986771..3987368 Replicon chromosome
Accession NZ_CP056425
Organism Klebsiella pneumoniae strain RHBSTW-00515

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag HV227_RS20050 Protein ID WP_004142563.1
Coordinates 3987051..3987368 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag HV227_RS20045 Protein ID WP_004142561.1
Coordinates 3986771..3987058 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV227_RS20015 3982852..3983100 + 249 WP_002893037.1 DUF1158 domain-containing protein -
HV227_RS20020 3983118..3983459 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
HV227_RS20025 3983490..3984605 - 1116 WP_074189222.1 MBL fold metallo-hydrolase -
HV227_RS20030 3984784..3985368 + 585 WP_002893026.1 TetR/AcrR family transcriptional regulator -
HV227_RS20035 3985365..3985733 + 369 WP_040171587.1 MmcQ/YjbR family DNA-binding protein -
HV227_RS20040 3985853..3986506 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
HV227_RS20045 3986771..3987058 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
HV227_RS20050 3987051..3987368 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV227_RS20055 3987553..3988596 - 1044 WP_048265289.1 DUF2157 domain-containing protein -
HV227_RS20060 3989266..3990132 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
HV227_RS20065 3990241..3991668 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T163470 WP_004142563.1 NZ_CP056425:c3987368-3987051 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T163470 NZ_CP072598:c1851857-1851387 [Duffyella gerundensis]
GTGAAGTTGTACCGCCTGACCAAAACGCGCTATCTGAGTTCTGCCTGGAGCGGTTACGGTGCCAGGGAAGGCGGCGGGCG
CTGGAATAACGTGGGCGTGTCGATGGTCTATGCGTCGGAAACCGCATCGCTGACCATGCTGGAAATACTGGTTCATCTGC
AAAGTGCCGCCACGCTGGATGCCTATACCTTGCTTTGTGTTGAGGTGCCCGATGGGCTGATTCAGTGGATTGATGTGACG
CAGTTACCGGAAAACTGGCGGGCGGCCGAAGCCCCGGCGGCGCTGCGTGAGATTGGTGATGCCTGGATCAGTAGCGGCGA
GTCGGTGGCGTTGCGCATACCCAGTGCGCTGTCGCCGGTGGAACATAACTTTTTGCTTAATCCGGATCATCCCGCCTTCA
CGGAGCAGGTCAGCCGCGCCAGCCATATTCCGTTTATGTTTGATTCACGCTTTGGTACGGCGCATTCCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT163470 WP_004142561.1 NZ_CP056425:c3987058-3986771 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT163470 NZ_CP072598:c1852297-1851854 [Duffyella gerundensis]
ATGAAACAGTTTACCTTACCTGCACGGCATCACTCGCCAGAACGCCTCTGGCAGGTTGCCGGGCTGAACAGCGCTGACGG
CGTGATGCTAATGGGGCAGATCGATCGCGGGCTGGAAGGCGCGGTGGCCAACCGTATTATTTCGTGGGCGCTGATGACCC
AGGCCGATTTGCGTCACGTGACCGGCATTCCTGCCACCACCTTTAACCGCGGCATGAAAGATCGCTTTACCGCCGAGCAG
AGCGAGCGCCTGGTGCGCTTTATTCGCGTGATGGATCGCGCCGTTGAGCTGTTTGAAGGCGATAAACACAAGGCGCAGCA
GTGGCTGAATGAGCCGGCAAGGGCGCTTGATAACAAAAAGCCTGCCGACCTGGTTTCATCGGAAACCGGCGCCTATGAGG
TACTGAAGCTGATTACCCGGCTTGAGCATGGTGTCTATTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References