Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5076711..5077310 Replicon chromosome
Accession NZ_CP056421
Organism Citrobacter sp. RHBSTW-00524

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV229_RS24300 Protein ID WP_131347312.1
Coordinates 5076999..5077310 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV229_RS24295 Protein ID WP_131347314.1
Coordinates 5076711..5076998 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV229_RS24280 5074207..5075109 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
HV229_RS24285 5075106..5075741 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
HV229_RS24290 5075738..5076667 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
HV229_RS24295 5076711..5076998 - 288 WP_131347314.1 helix-turn-helix domain-containing protein Antitoxin
HV229_RS24300 5076999..5077310 - 312 WP_131347312.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV229_RS24305 5077531..5078460 + 930 WP_181546576.1 alpha/beta hydrolase -
HV229_RS24310 5078545..5078856 + 312 WP_019077936.1 type II toxin-antitoxin system HigB family toxin -
HV229_RS24315 5078853..5079305 + 453 WP_104651900.1 helix-turn-helix domain-containing protein -
HV229_RS24320 5079323..5080264 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
HV229_RS24325 5080309..5080746 - 438 WP_016157874.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV229_RS24330 5080743..5081615 - 873 WP_019077938.1 virulence factor BrkB family protein -
HV229_RS24335 5081609..5082208 - 600 WP_016157873.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5076711..5090892 14181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12345.46 Da        Isoelectric Point: 9.8882

>T163454 WP_131347312.1 NZ_CP056421:c5077310-5076999 [Citrobacter sp. RHBSTW-00524]
MLFIETEIFTEDVKKLLDDDEYRRLQIFLAIQPDCGDLIQETGGLRKVRWRARGKGKRGGVRIIYFHQIRESQIRLLLIY
QKGIKDDLTPQEKVLLRMLNERW

Download         Length: 312 bp

>T163454 NZ_CP072579:468988-469329 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATACGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10746.39 Da        Isoelectric Point: 11.1842

>AT163454 WP_131347314.1 NZ_CP056421:c5076998-5076711 [Citrobacter sp. RHBSTW-00524]
MDKALFERLTQSMVQMNEIAEGTRQPSRTFHIDAMKIKEIRLSSGLSQTRFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPKHVIQALR

Download         Length: 288 bp

>AT163454 NZ_CP072579:468758-468988 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References