Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1780..2281 Replicon plasmid pRHBSTW-00570_4
Accession NZ_CP056402
Organism Citrobacter sp. RHBSTW-00570

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7L6INF2
Locus tag HV237_RS25810 Protein ID WP_072058806.1
Coordinates 2006..2281 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7L6INP2
Locus tag HV237_RS25805 Protein ID WP_047359280.1
Coordinates 1780..2025 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV237_RS25800 1144..1350 + 207 WP_047359279.1 hypothetical protein -
HV237_RS25805 1780..2025 + 246 WP_047359280.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HV237_RS25810 2006..2281 + 276 WP_072058806.1 Txe/YoeB family addiction module toxin Toxin
HV237_RS25815 2452..3432 - 981 WP_000019452.1 IS5-like element ISKpn26 family transposase -
HV237_RS25820 3583..4476 + 894 WP_047359282.1 GalU regulator GalF -
HV237_RS25825 4822..5802 - 981 WP_181541876.1 IS5 family transposase -
HV237_RS25830 5895..6311 + 417 WP_052951298.1 hypothetical protein -
HV237_RS25835 6311..7117 + 807 WP_047359263.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - galF 1..34198 34198
- inside IScluster/Tn - galF 49..5802 5753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10856.34 Da        Isoelectric Point: 10.3145

>T163421 WP_072058806.1 NZ_CP056402:2006-2281 [Citrobacter sp. RHBSTW-00570]
MSKWNIKFTKNGADDINYWRGTDKKKFERIRQLLHSIESDPLTGIGKPERLRHHKDPALYSRRIDQSHRLVYSIQNGEII
IYAARYHYGDK

Download         Length: 276 bp

>T163421 NZ_CP072565:2677345-2677452 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9276.43 Da        Isoelectric Point: 4.5069

>AT163421 WP_047359280.1 NZ_CP056402:1780-2025 [Citrobacter sp. RHBSTW-00570]
MHAITFTDARKHFADTMKRVTDDAEPVRVMRRDAPDIVMIDAGEYEALIETVYLFSNPANAAHINESMKQAERGEFVEVE
Y

Download         Length: 246 bp

>AT163421 NZ_CP072565:c2677298-2677232 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6INF2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6INP2

References