Detailed information of TA system TA163291

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 353262..353908
• Replicon: chromosome
• Accession: NZ_CP056329
• Organism: Klebsiella pneumoniae strain RHBSTW-00807

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HV282_RS01650
• Protein ID: WP_038808408.1
• Coordinates: 353262..353609 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: W8UB68
• Locus tag: HV282_RS01655
• Protein ID: WP_002920557.1
• Coordinates: 353609..353908 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV282_RS01640	349188..350621	+	1434	WP_002920564.1	glycogen synthase GlgA	-
HV282_RS01645	350639..353086	+	2448	WP_002920561.1	glycogen phosphorylase	-
HV282_RS01650	353262..353609	+	348	WP_038808408.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV282_RS01655	353609..353908	+	300	WP_002920557.1	helix-turn-helix transcriptional regulator	Antitoxin
HV282_RS01660	353971..355479	-	1509	WP_002920554.1	glycerol-3-phosphate dehydrogenase	-
HV282_RS01665	355684..356013	+	330	WP_002920552.1	thiosulfate sulfurtransferase GlpE	-
HV282_RS01670	356064..356894	+	831	WP_004151408.1	rhomboid family intramembrane serine protease GlpG	-
HV282_RS01675	356944..357702	+	759	WP_002920548.1	DeoR/GlpR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (9-87)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13519.53 Da
• Isoelectric Point: 5.6749

>T163291 WP_038808408.1 NZ_CP056329:353262-353609 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Nucleotide

• Length: 348 bp

>T163291 NZ_CP072496:4050893-4051111 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10800.58 Da
• Isoelectric Point: 10.1464

>AT163291 WP_002920557.1 NZ_CP056329:353609-353908 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Nucleotide

• Length: 300 bp

>AT163291 NZ_CP072496:4050492-4050866 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A0E1CBF8