Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 387783..388429 Replicon chromosome
Accession NZ_CP056307
Organism Klebsiella pneumoniae strain RHBSTW-00832

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag HV292_RS01850 Protein ID WP_004174016.1
Coordinates 387783..388130 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F2LZT5
Locus tag HV292_RS01855 Protein ID WP_008806992.1
Coordinates 388130..388429 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV292_RS01840 383709..385142 + 1434 WP_002920564.1 glycogen synthase GlgA -
HV292_RS01845 385160..387607 + 2448 WP_002920561.1 glycogen phosphorylase -
HV292_RS01850 387783..388130 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV292_RS01855 388130..388429 + 300 WP_008806992.1 helix-turn-helix transcriptional regulator Antitoxin
HV292_RS01860 388492..390000 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
HV292_RS01865 390205..390534 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
HV292_RS01870 390585..391415 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
HV292_RS01875 391465..392223 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T163248 WP_004174016.1 NZ_CP056307:387783-388130 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T163248 NZ_CP072467:1118365-1118622 [Spiractinospora alimapuensis]
GTGAGAGTGGTTTTCACTCCCCACGGTTGGGAGGACTACACCCACTGGCTCTCGGCGGACCGATCAACTCTGAAACGCAT
CAACCGGTTGATCGACGACATCCTGAGAGATCCCTTCGAAGGCATCGGCAAACCTGAACCGCTGCGGCACGCGTTCGCCG
GTGCCTGGTCGCGACGCATCAGTGAAGAGCACAGACTCGTCTATCTGGTGGACGACGAGGACATCGTGATTCTCCAGGCC
CGCTATCACTACAACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10814.61 Da        Isoelectric Point: 10.1464

>AT163248 WP_008806992.1 NZ_CP056307:388130-388429 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT163248 NZ_CP072467:1118123-1118368 [Spiractinospora alimapuensis]
ATGGCAATCACCGCGTCCGAGGCGCGCAAGCACCTCTTCCCACTCATCGAAAAGGTCAACGACGACCGAGCACCCGTGGA
AATCACGTCCCGCCGGGGTGATGCCGTACTGATCTCCAAGGAAGACTACGAAGCCCTGGAAGAGACCGCGCATCTGCTCC
GGTCTCCGGCGAACGCCCGCCGCCTGCTGGAGAGCCTGGCCCAAGCACGGCGCGATGAACGCCACGAGCACTCCCTAGCC
GAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZT5

References