Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 361593..362179 Replicon chromosome
Accession NZ_CP056307
Organism Klebsiella pneumoniae strain RHBSTW-00832

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag HV292_RS01740 Protein ID WP_002920800.1
Coordinates 361811..362179 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag HV292_RS01735 Protein ID WP_004174006.1
Coordinates 361593..361814 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV292_RS01715 357750..358676 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
HV292_RS01720 358673..359950 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
HV292_RS01725 359947..360714 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HV292_RS01730 360716..361429 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
HV292_RS01735 361593..361814 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HV292_RS01740 361811..362179 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HV292_RS01745 362452..363768 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
HV292_RS01750 363875..364762 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
HV292_RS01755 364759..365604 + 846 WP_004185988.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
HV292_RS01760 365606..366676 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 356579..367413 10834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T163247 WP_002920800.1 NZ_CP056307:361811-362179 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T163247 NZ_CP072467:1118123-1118368 [Spiractinospora alimapuensis]
ATGGCAATCACCGCGTCCGAGGCGCGCAAGCACCTCTTCCCACTCATCGAAAAGGTCAACGACGACCGAGCACCCGTGGA
AATCACGTCCCGCCGGGGTGATGCCGTACTGATCTCCAAGGAAGACTACGAAGCCCTGGAAGAGACCGCGCATCTGCTCC
GGTCTCCGGCGAACGCCCGCCGCCTGCTGGAGAGCCTGGCCCAAGCACGGCGCGATGAACGCCACGAGCACTCCCTAGCC
GAGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT163247 WP_004174006.1 NZ_CP056307:361593-361814 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT163247 NZ_CP072467:1118365-1118622 [Spiractinospora alimapuensis]
GTGAGAGTGGTTTTCACTCCCCACGGTTGGGAGGACTACACCCACTGGCTCTCGGCGGACCGATCAACTCTGAAACGCAT
CAACCGGTTGATCGACGACATCCTGAGAGATCCCTTCGAAGGCATCGGCAAACCTGAACCGCTGCGGCACGCGTTCGCCG
GTGCCTGGTCGCGACGCATCAGTGAAGAGCACAGACTCGTCTATCTGGTGGACGACGAGGACATCGTGATTCTCCAGGCC
CGCTATCACTACAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References