Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 83097..83960 Replicon plasmid pRHBSTW-00902_3
Accession NZ_CP056258
Organism Citrobacter freundii strain RHBSTW-00902

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag HV319_RS26455 Protein ID WP_127785371.1
Coordinates 83097..83591 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag HV319_RS26460 Protein ID WP_079940153.1
Coordinates 83616..83960 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV319_RS26425 78121..78669 - 549 WP_127785946.1 DUF1380 family protein -
HV319_RS26430 79155..79934 - 780 WP_153983909.1 hypothetical protein -
HV319_RS26435 80094..80942 - 849 WP_044702681.1 DUF4942 domain-containing protein -
HV319_RS26440 81060..81275 - 216 WP_044702680.1 hypothetical protein -
HV319_RS26445 81344..82024 - 681 WP_153983908.1 hypothetical protein -
HV319_RS26450 82122..82370 - 249 WP_136138507.1 hypothetical protein -
HV319_RS26455 83097..83591 - 495 WP_127785371.1 type II toxin-antitoxin system YhaV family toxin Toxin
HV319_RS26460 83616..83960 - 345 WP_079940153.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
HV319_RS26465 84306..84524 - 219 WP_153983907.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HV319_RS26470 84777..85007 - 231 WP_044702671.1 hypothetical protein -
HV319_RS26475 84998..85261 - 264 WP_044702670.1 DUF1380 family protein -
HV319_RS26480 85368..85649 - 282 WP_044702669.1 hypothetical protein -
HV319_RS26485 85797..86315 - 519 WP_079940146.1 hypothetical protein -
HV319_RS26490 86305..86679 - 375 WP_079940147.1 hypothetical protein -
HV319_RS26495 86689..87018 - 330 WP_079940148.1 hypothetical protein -
HV319_RS26500 87032..87382 - 351 WP_079940149.1 hypothetical protein -
HV319_RS26505 87397..87828 - 432 WP_153983905.1 antirestriction protein -
HV319_RS26510 88012..88443 - 432 WP_079940151.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..100185 100185


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(11-147)

Antitoxin

PrlF antitoxin

(16-114)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 19100.97 Da        Isoelectric Point: 8.6573

>T163166 WP_127785371.1 NZ_CP056258:c83591-83097 [Citrobacter freundii]
MEYLEINGWKICFHKCFLDQIVELAQKVAELKAAKPSEYHTKKETKLLRAIERVIEEWIASDPLNPQYRQGETLGDEYKH
WFRVKFLQQFRLFFRCSQEHKTIIIGWVNDFGTLRAYGSKTDAYKVFAAMLNAGNPPDDWDKLLNAATKATAKASIPDFL
TRQP

Download         Length: 495 bp

>T163166 NZ_CP072422:c2693332-2692010 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGAGAGCAGATGTTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12535.20 Da        Isoelectric Point: 4.4227

>AT163166 WP_079940153.1 NZ_CP056258:c83960-83616 [Citrobacter freundii]
MATQILNSADVSLRAESRLTERSQTTIPAAIRDALHLKPGESIHYTLLAGGKVIMSRKDEEQDDPVVSQFLAFLENDMKK
NPQNIAPVPAFFWESIKALTAGVEVDLDAPLTDD

Download         Length: 345 bp

>AT163166 NZ_CP072422:c2693598-2693332 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References