Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 326898..327564 | Replicon | chromosome |
Accession | NZ_CP056245 | ||
Organism | Citrobacter freundii strain RHBSTW-00915 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A8B5Q945 |
Locus tag | HV325_RS01535 | Protein ID | WP_003847996.1 |
Coordinates | 327247..327564 (-) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A4U6IRD5 |
Locus tag | HV325_RS01530 | Protein ID | WP_003837894.1 |
Coordinates | 326898..327194 (-) | Length | 99 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV325_RS01515 | 324074..324547 | - | 474 | WP_003023524.1 | transcription elongation factor GreB | - |
HV325_RS01520 | 324773..325492 | + | 720 | WP_001157751.1 | two-component system response regulator OmpR | - |
HV325_RS01525 | 325489..326841 | + | 1353 | WP_003837891.1 | two-component system sensor histidine kinase EnvZ | - |
HV325_RS01530 | 326898..327194 | - | 297 | WP_003837894.1 | helix-turn-helix domain-containing protein | Antitoxin |
HV325_RS01535 | 327247..327564 | - | 318 | WP_003847996.1 | hypothetical protein | Toxin |
HV325_RS01540 | 327687..329309 | - | 1623 | WP_003023529.1 | phosphoenolpyruvate carboxykinase (ATP) | - |
HV325_RS01545 | 329688..331406 | + | 1719 | WP_049014788.1 | DUF4153 domain-containing protein | - |
HV325_RS01550 | 331516..332394 | - | 879 | WP_003023531.1 | Hsp33 family molecular chaperone HslO | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12225.15 Da Isoelectric Point: 10.0909
>T163108 WP_003847996.1 NZ_CP056245:c327564-327247 [Citrobacter freundii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI
Download Length: 318 bp
>T163108 NZ_CP072385:c969019-968618 [Arachnia propionica]
ATGATCGTCGACCCGTCTGCGATTGCCGCCATCCTGCTGAAGGAGCCGGAGAGCAGCGGCTTCCGTGAGCTGCTGGGCAG
GCGTGGCGGCCAATTGTCCGCCCCCGGTTACCTGGAGTTGTCGATCGTGCTCACGGCGCGGGGAGTCACCGACCCCGTCG
CCACCCTCGATGCGATCCTGCTCGGCCTCGGCGTGGAGGTGGTGCCTTTCACGCCGTCACAGGCTCGCCTGGCTCAGGAG
GCCCACCTGCGTTTCGGCAGGGGCAGCGGCCATCCGGCCAGGCTGAACTTCGGTGACTGCATCAGCTACGCCCTCGCCAA
GGACACCGGGGAACCCCTTTTGTTCAAGGGAAACGACTTCGTCCACACCGATCTGAACCCCGCCTCCGGGATCTCACCCT
GA
ATGATCGTCGACCCGTCTGCGATTGCCGCCATCCTGCTGAAGGAGCCGGAGAGCAGCGGCTTCCGTGAGCTGCTGGGCAG
GCGTGGCGGCCAATTGTCCGCCCCCGGTTACCTGGAGTTGTCGATCGTGCTCACGGCGCGGGGAGTCACCGACCCCGTCG
CCACCCTCGATGCGATCCTGCTCGGCCTCGGCGTGGAGGTGGTGCCTTTCACGCCGTCACAGGCTCGCCTGGCTCAGGAG
GCCCACCTGCGTTTCGGCAGGGGCAGCGGCCATCCGGCCAGGCTGAACTTCGGTGACTGCATCAGCTACGCCCTCGCCAA
GGACACCGGGGAACCCCTTTTGTTCAAGGGAAACGACTTCGTCCACACCGATCTGAACCCCGCCTCCGGGATCTCACCCT
GA
Antitoxin
Download Length: 99 a.a. Molecular weight: 11157.93 Da Isoelectric Point: 7.2050
>AT163108 WP_003837894.1 NZ_CP056245:c327194-326898 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI
Download Length: 297 bp
>AT163108 NZ_CP072385:c969261-969016 [Arachnia propionica]
GTGAGTTTGAACATCAAGGACGAGCACATCCACGACCTGGTCCGTCGGGCCGCCACCCGGACGGGGCTGAGTCAGACCCG
CGTGGTCGAACGGGCCGTGGTTGAGCTGCTGGCCTCCCTGGAAGCGGAAGCCGCCGCCTCCGGTCTCGATCAGCTCCTGG
ACCGGGTGCATGCCGAGCTCACGGCCTCCGGCGGCGCCCTGGACTTCGACGCCCTCTACGACCCCGAGACGGGGTTGCCG
CGATGA
GTGAGTTTGAACATCAAGGACGAGCACATCCACGACCTGGTCCGTCGGGCCGCCACCCGGACGGGGCTGAGTCAGACCCG
CGTGGTCGAACGGGCCGTGGTTGAGCTGCTGGCCTCCCTGGAAGCGGAAGCCGCCGCCTCCGGTCTCGATCAGCTCCTGG
ACCGGGTGCATGCCGAGCTCACGGCCTCCGGCGGCGCCCTGGACTTCGACGCCCTCTACGACCCCGAGACGGGGTTGCCG
CGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B5Q945 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4U6IRD5 |