Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 77384..78247 Replicon plasmid pRHBSTW-00935_3
Accession NZ_CP056240
Organism Citrobacter freundii strain RHBSTW-00935

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag HV330_RS26450 Protein ID WP_127785371.1
Coordinates 77753..78247 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag HV330_RS26445 Protein ID WP_079940153.1
Coordinates 77384..77728 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV330_RS26395 72901..73332 + 432 WP_079940151.1 hypothetical protein -
HV330_RS26400 73516..73947 + 432 WP_153983905.1 antirestriction protein -
HV330_RS26405 73962..74312 + 351 WP_079940149.1 hypothetical protein -
HV330_RS26410 74326..74655 + 330 WP_079940148.1 hypothetical protein -
HV330_RS26415 74665..75039 + 375 WP_079940147.1 hypothetical protein -
HV330_RS26420 75029..75547 + 519 WP_079940146.1 hypothetical protein -
HV330_RS26425 75695..75976 + 282 WP_044702669.1 hypothetical protein -
HV330_RS26430 76083..76346 + 264 WP_044702670.1 DUF1380 family protein -
HV330_RS26435 76337..76567 + 231 WP_044702671.1 hypothetical protein -
HV330_RS26440 76820..77038 + 219 WP_153983907.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HV330_RS26445 77384..77728 + 345 WP_079940153.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
HV330_RS26450 77753..78247 + 495 WP_127785371.1 type II toxin-antitoxin system YhaV family toxin Toxin
HV330_RS26455 78974..79222 + 249 WP_136138507.1 hypothetical protein -
HV330_RS26460 79320..80000 + 681 WP_153983908.1 hypothetical protein -
HV330_RS26465 80069..80284 + 216 WP_044702680.1 hypothetical protein -
HV330_RS26470 80402..81250 + 849 WP_044702681.1 DUF4942 domain-containing protein -
HV330_RS26475 81410..82189 + 780 WP_153983909.1 hypothetical protein -
HV330_RS26480 82675..83223 + 549 WP_127785946.1 DUF1380 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..100185 100185


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(11-147)

Antitoxin

PrlF antitoxin

(16-114)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 19100.97 Da        Isoelectric Point: 8.6573

>T163090 WP_127785371.1 NZ_CP056240:77753-78247 [Citrobacter freundii]
MEYLEINGWKICFHKCFLDQIVELAQKVAELKAAKPSEYHTKKETKLLRAIERVIEEWIASDPLNPQYRQGETLGDEYKH
WFRVKFLQQFRLFFRCSQEHKTIIIGWVNDFGTLRAYGSKTDAYKVFAAMLNAGNPPDDWDKLLNAATKATAKASIPDFL
TRQP

Download         Length: 495 bp

>T163090 NZ_CP072329:350026-350796 [Streptococcus lactarius]
ATGAAACTAGAAGAGTTTAGTCAAGATGATTTTGAACGAGCATCCAGACGACTCGTTCGTTCTTTAACTCGTGGTAAAAC
AACTTCGTCTCAGCCCAAGGCTATCTTGCTAGGTGGACAGAGTGGTGCTGGGAAAACTACGATTCATCGTATTAAACAAA
GGGAATTTCAAGGAAATATCATTATAATTGATGGAGATAGTTATCGCTCTTTTCATCCCAACTACCTTGACCTACAGGAA
AAGTATGGCAAAGATAGTGTGGATTATACCAAGGTTTTTGCGGGAAAAATGGTTGAATATCTCGTAGATGAATTGAGTAA
ACTAGGCTATCATTTGTTAATCAAGGGAACCTTGAGAACAACAGAAGTTCCTAGAAAAACGGCACAATTATTGACAACTA
GAGGTTACCAAGTCTCACTTGCACTGATTGCGACCAAGCCTGAATTGTCCTATATTAGCACCTTGATACGTTACGGAGAG
CTCTATGCTATAGATCCTCGTCAAGCTAGAGCGACTCCCAAAGAGCACCATGATGGAATTGTAGAACATTTAGTTGATAA
CTTACGAGAGCTAGAAAATAACAAGATTTTTAATCAAATTCAAATTTTTCAAAGAGATCAATCGTGCGTTTATGATTCGC
AAGTAGATCAAACCTCAGCAGCAGAAGTTCTACACGAATGCCTCTTCGGAAAATTGAGTAAGGTGGAGAAAGAAATGTTG
AAGTTGGGACAAGAACGGTTGAGGGAGTTCAACACGGAAACTAAAAAGTAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12535.20 Da        Isoelectric Point: 4.4227

>AT163090 WP_079940153.1 NZ_CP056240:77384-77728 [Citrobacter freundii]
MATQILNSADVSLRAESRLTERSQTTIPAAIRDALHLKPGESIHYTLLAGGKVIMSRKDEEQDDPVVSQFLAFLENDMKK
NPQNIAPVPAFFWESIKALTAGVEVDLDAPLTDD

Download         Length: 345 bp

>AT163090 NZ_CP072329:349550-350026 [Streptococcus lactarius]
ATGATCGGAGAAAATATTAAAGCGTTACGTAAAACACATAACCTAACCCAGCCTGAGTTCGCAAAGATTGTTGGTATCTC
TCGAAATAGCCTAAGTCGTTATGAAAATGGAACAAGTTCAATTTCGACAGAATTAATAGATCGTATCTGCCAGAAATTTA
ATGTTTCCTATATCGATATCGTAGGGGAGGAAAAGATGCTCACACCAGTAGAAGATTACCAGTTGACCCTGAAAATTGAA
GTGATTAAAGAACGAGGGGCGAATATCTTAGCGCAACTTTATCGTTTTCAAGATGAACAAGGAATTGCATTTGATGATAC
TTCTAATCCTTGGGTTCTAATGAGCGATGATTTGTCTGATTTGCTGAACACGAAGATTTATCTTGTGGGGACTTTTGATG
AAGTAGAGCGATTTAATGGCTATTTGGATGGCATTGAACGGATGCTAGAACAAGCTAGTCATCTGGTGGTGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References